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(-)-Syringaresinol

Cat. No. M10660
(-)-Syringaresinol Structure
Size Price Availability Quantity
2mg USD 300  USD300 In stock
5mg USD 450  USD450 In stock
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Biological Activity

(-)-Syringaresinol has anti-cancer activity.

Chemical Information
Molecular Weight 418.44
Formula C22H26O8
CAS Number 6216-81-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yuzhen Zhuo, et al. Inflammation. Syringaresinol Resisted Sepsis-Induced Acute Lung Injury by Suppressing Pyroptosis Via the Oestrogen Receptor-β Signalling Pathway

[2] Ao Wei, et al. Eur J Pharmacol. Syringaresinol attenuates sepsis-induced cardiac dysfunction by inhibiting inflammation and pyroptosis in mice

[3] Verena Kirsch, et al. Curr Res Toxicol. Toxicological testing of syringaresinol and enterolignans

[4] Lanqiu Zhang, et al. Int Immunopharmacol. (-)-Syringaresinol suppressed LPS-induced microglia activation via downregulation of NF-κB p65 signaling and interaction with ERβ

[5] Desen Yang, et al. Food Chem Toxicol. (-)-Syringaresinol-4-O-β-D-glucopyranoside from Cortex Albizziae inhibits corticosterone-induced PC12 cell apoptosis and relieves the associated dysfunction

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