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Licoricesaponin A3

Cat. No. M39980
Licoricesaponin A3 Structure
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Biological Activity

Licoricesaponin A3 is a terpenoid saponin identified from licorice.

Chemical Information
Molecular Weight 985.07
Formula C48H72O21
CAS Number 118325-22-7
Form Solid
Storage 4°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yang Yi et al. J Pharm Anal. Licorice-saponin A3 is a broad-spectrum inhibitor for COVID-19 by targeting viral spike and anti-inflammation

[2] Yang Yi et al. J Adv Res. Natural triterpenoids from licorice potently inhibit SARS-CoV-2 infection

[3] Jinfang Xu et al. J Sep Sci. Simultaneous separation of triterpenoid saponins and flavonoid glycosides from the roots of Glycyrrhiza uralensis Fisch by pH-zone-refining counter-current chromatography

[4] I Kitagawa et al. Chem Pharm Bull (Tokyo). Saponin and sapogenol. XLVII. On the constituents of the roots of Glycyrrhiza uralensis Fischer from northeastern China. (1). Licorice-saponins A3, B2, and C2

[5] I Kitagawa et al. Chem Pharm Bull (Tokyo). Saponin and sapogenol. L. On the constituents of the roots of Glycyrrhiza uralensis Fischer from Xinjiang, China. Chemical structures of licorice-saponin L3 and isoliquiritin apioside

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