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Kauniolide

Cat. No. M40096
Kauniolide Structure
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Biological Activity

Kauniolide(81066-45-7) is a natural compound.

Chemical Information
Molecular Weight 230.3
Formula C15H18O2
CAS Number 81066-45-7
Form Solid
Solubility (25°C) DMSO 90 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Charlotte De Bruyn et al. Front Plant Sci. Identification and characterization of CYP71 subclade cytochrome P450 enzymes involved in the biosynthesis of bitterness compounds in Cichorium intybus

[2] Omar Malagón et al. Plants (Basel). Essential Oil and Non-Volatile Metabolites from Kaunia longipetiolata (Sch.Bip. ex Rusby) R. M. King and H. Rob., an Andean Plant Native to Southern Ecuador

[3] Katarina Cankar et al. Front Plant Sci. CRISPR/Cas9 targeted inactivation of the kauniolide synthase in chicory results in accumulation of costunolide and its conjugates in taproots

[4] Sihyun Baek et al. Metab Eng. The yeast platform engineered for synthetic gRNA-landing pads enables multiple gene integrations by a single gRNA/Cas9 system

[5] Qing Liu et al. Nat Commun. Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity

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