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Jervine

Cat. No. M3995

Jervine Structure

Synonym: 11-Ketocyclopamine

Size Price Availability Quantity
5mg USD 130 In stock
10mg USD 230 In stock
50mg USD 920 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Jervine inhibits the sonic hedgehog (shh) pathway by interacting with smoothened. Jervine can be used to induce abnormal morphogenesis in a number of experimental models.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 425.6
Formula C27H39NO3
CAS Number 469-59-0
Purity >99%
Solubility DMSO 5mg/ml
Ethanol 10mg/ml
Storage at -20°C
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LDE225 Diphosphate

LDE225 Diphosphate is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.

GANT61

GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM.

PF-5274857

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LDE225

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Jervine, 11-Ketocyclopamine supplier, Hedgehog, inhibitors

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