|M4865||Smoothened Agonist (SAG) HCl||Smoothened Agonist (SAG) HCl is a cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells.|
|M4841||LDE225 Diphosphate||LDE225 Diphosphate is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.|
|M3995||Jervine||Jervine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog signaling.|
|M2448||GANT61||GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM.|
|M2447||PF-5274857||PF-5274857 is a novel Smoothened antagonist, inhibits Hedgehog signaling with IC50 and Ki values of 5.8 nM and 4.6 nM, respectively.|
|M2338||LDE225||LDE225 (NVP-LDE225) is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.|
|M2110||LY2940680||LY2940680 is a potent Hedgehog inhibitor with potential anticancer activity.|
|M1975||Cyclopamine||Cyclopamine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog signaling.|
|M1874||Purmorphamine||Purmorphamine is a small molecule Hh agonist which activates the hedgehog pathway by directly binding to SMO.|
|M1812||GANT58||GANT58 is a cell-permeable GLI antagonist that inhibits GLI1-induced transcription (IC50 = 5 μM).|
|M1713||GDC-0449||GDC-0449 (Vismodegib) is a potent and specific hedgehog pathway inhibitor with IC50 values of 1.4 and 3.0μM for inhibition of ABCG2 and Pgp respectively.|
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