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Hedgehog

Cat.No.  Name Information
M2338 LDE225 LDE225 (NVP-LDE225; Sonidegib) is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.
M27826 Robotnikinin  Robotnikinin is a small molecule capable of binding to and inhibiting the activity of Sonic Hedgehog (Shh) signaling up stream of Smo.
M14923 Ciliobrevin D Ciliobrevin D is a cell-permeable, reversible and specific inhibitor of AAA+ ATPase motor cytoplasmic dynein.
M6843 JK 184 JK 184 is a alcohol dehydrogenase 7 inhibitor; inhibits downstream Hh signaling pathway.
M6149 HPI-4 HPI-4 (Ciliobrevin A) is a hedgehog (Hh) pathway antagonist. It blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50 = 7 μM) downstream of Smo.
M3995 Jervine Jervine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog signaling.
M2447 PF-5274857 PF-5274857 is a novel Smoothened antagonist, inhibits Hedgehog signaling with IC50 and Ki values of 5.8 nM and 4.6 nM, respectively.
M2110 LY2940680 LY2940680 is a potent Hedgehog inhibitor with potential anticancer activity.
M1975 Cyclopamine Cyclopamine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog signaling.
M45320 TPB15 TPB15 is an orally potent Hh (Hedgehog) signaling inhibitor that significantly induces MDA-MB-468 cell cycle arrest and apoptosis. TPB15 also blocks Smo (Smoothened) translocation into cilia and reduces Smo protein and mRNA expression. In addition, TPB15 can inhibit the expression of downstream regulator Glioma-associated oncogene 1 (Gli1). TPB15 has good anti-tumor activity and low toxicity.
M43557 Hedgehog IN-3 Hedgehog IN-3 is a hedgehog pathway inhibitor (IC50 = 0.01 µM).
M43556 Hedgehog IN-5 Hedgehog IN-5 is an orally active small molecule inhibitor of the hedgehog pathway.
M43555 Hedgehog IN-2 Hedgehog IN-2 is an inhibitor of Hedgehog pathway with an IC50 value less than 0.003 μM in C3H10T1/2 cells.
M39852 Physalin H Physalin H is an inhibitor of Hedgehog (Hh) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC50 value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC50 values of 5.7 and 6.8 μM, respectively.
M27901 TAK-441  TAK-441 is a highly potent and orally active hedgehog (Hh) signaling inhibitor with an IC50value of 4.4 nM. TAK-441 has strong antitumor activity in solid tumors.
M14925 Hh-Ag1.5 Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC50 of 1 nM. Hh-Ag1.5 mediated reprogramming breaks the quiescence of noninjured liver stem cells for rescuing liver failure.
M14924 Dynarrestin Dynarrestin is a aminothiazole inhibitor of cytoplasmic dyneins 1 and 2.
M6474 AY 9944 dihydrochloride AY 9944 dihydrochloride is a inhibitor of Hedgehog (Hh) signaling. Inhibits Δ 7-dehydrocholesterol reductase.




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