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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M4865 | Smoothened Agonist (SAG) HCl | Smoothened Agonist (SAG) HCl is a cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells. |
| M4841 | LDE225 Diphosphate | LDE225 Diphosphate is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively. |
| M3995 | Jervine | Jervine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog signaling. |
| M2448 | GANT61 | GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM. |
| M2447 | PF-5274857 | PF-5274857 is a novel Smoothened antagonist, inhibits Hedgehog signaling with IC50 and Ki values of 5.8 nM and 4.6 nM, respectively. |
| M2338 | LDE225 | LDE225 (NVP-LDE225) is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively. |
| M2110 | LY2940680 | LY2940680 is a potent Hedgehog inhibitor with potential anticancer activity. |
| M1975 | Cyclopamine | Cyclopamine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog signaling. |
| M1874 | Purmorphamine | Purmorphamine is a small molecule Hh agonist which activates the hedgehog pathway by directly binding to SMO. |
| M1812 | GANT58 | GANT58 is a cell-permeable GLI antagonist that inhibits GLI1-induced transcription (IC50 = 5 μM). |
| M1713 | GDC-0449 | GDC-0449 (Vismodegib) is a potent and specific hedgehog pathway inhibitor with IC50 values of 1.4 and 3.0μM for inhibition of ABCG2 and Pgp respectively. |
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