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Abmole Inhibitor Catalog 2017

Hedgehog

Inhibitors

Cat.No.  Name Information
M4865 Smoothened Agonist (SAG) HCl Smoothened Agonist (SAG) HCl is a cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells.
M4841 LDE225 Diphosphate LDE225 Diphosphate is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.
M3995 Jervine Jervine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog signaling.
M2448 GANT61 GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM.
M2447 PF-5274857 PF-5274857 is a novel Smoothened antagonist, inhibits Hedgehog signaling with IC50 and Ki values of 5.8 nM and 4.6 nM, respectively.
M2338 LDE225 LDE225 (NVP-LDE225) is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.
M2110 LY2940680 LY2940680 is a potent Hedgehog inhibitor with potential anticancer activity.
M1975 Cyclopamine Cyclopamine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog signaling.
M1874 Purmorphamine Purmorphamine is a small molecule Hh agonist which activates the hedgehog pathway by directly binding to SMO.
M1812 GANT58 GANT58 is a cell-permeable GLI antagonist that inhibits GLI1-induced transcription (IC50 = 5 μM).
M1713 GDC-0449 GDC-0449 (Vismodegib) is a potent and specific hedgehog pathway inhibitor with IC50 values of 1.4 and 3.0μM for inhibition of ABCG2 and Pgp respectively.

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