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Hedgehog IN-2

Cat. No. M43555
Hedgehog IN-2 Structure
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Biological Activity

Hedgehog IN-2 is an inhibitor of Hedgehog pathway with an IC50 value less than 0.003 μM in C3H10T1/2 cells.

Chemical Information
Molecular Weight 398.46
Formula C24H22N4O2
CAS Number 1126365-74-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Victor Pereira et al. Neurooncol Adv. Clinical and molecular analysis of smoothened inhibitors in Sonic Hedgehog medulloblastoma

[2] Ryan Dobbs et al. Exp Neurol. Sonic hedgehog regulation of cavernous nerve regeneration and neurite formation in aged pelvic plexus

[3] Cristina R Antonescu et al. Am J Surg Pathol. A Distinct Malignant Epithelioid Neoplasm With GLI1 Gene Rearrangements, Frequent S100 Protein Expression, and Metastatic Potential: Expanding the Spectrum of Pathologic Entities With ACTB/MALAT1/PTCH1-GLI1 Fusions

[4] Winnie W Lo et al. Cancer. Involvement and targeted intervention of dysregulated Hedgehog signaling in osteosarcoma

[5] Yi Ren et al. Biol Reprod. Overactivation of hedgehog signaling alters development of the ovarian vasculature in mice

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Keywords: Hedgehog IN-2 supplier, Hedgehog, inhibitors, activators

 
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