Free shipping on all orders over $ 500

Hedgehog IN-3

Cat. No. M43557
Hedgehog IN-3 Structure
Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?
Quality Control & Documentation
Biological Activity

Hedgehog IN-3 is a hedgehog pathway inhibitor (IC50 = 0.01 µM).

Chemical Information
Molecular Weight 407.78
Formula C18H13ClF3N5O
CAS Number 1128191-09-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Masahiro Fukuyama et al. J Dermatol. Activators of WNT, sonic hedgehog and ectodysplasin A signaling pathways exert synergetic influence on folliculogenic epithelial-mesenchymal interactions in 3-D skin equivalents: An implication for regenerative medicine

[2] Atsushi Otsuka et al. Clin Cancer Res. Hedgehog pathway inhibitors promote adaptive immune responses in basal cell carcinoma

[3] Yandong Shi et al. Clin Cancer Res. Role of hedgehog signaling in malignant pleural mesothelioma

[4] Wesley O Greaves et al. Hum Pathol. Glioma-associated oncogene homologue 3, a hedgehog transcription factor, is highly expressed in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma

[5] Shibani Mukherjee et al. Cancer Biol Ther. Hedgehog signaling and response to cyclopamine differ in epithelial and stromal cells in benign breast and breast cancer

Related Hedgehog Products
TPB15

TPB15 is an orally potent Hh (Hedgehog) signaling inhibitor that significantly induces MDA-MB-468 cell cycle arrest and apoptosis. TPB15 also blocks Smo (Smoothened) translocation into cilia and reduces Smo protein and mRNA expression. In addition, TPB15 can inhibit the expression of downstream regulator Glioma-associated oncogene 1 (Gli1). TPB15 has good anti-tumor activity and low toxicity.
Hedgehog IN-5

Hedgehog IN-5 is an orally active small molecule inhibitor of the hedgehog pathway.
Hedgehog IN-2

Hedgehog IN-2 is an inhibitor of Hedgehog pathway with an IC50 value less than 0.003 μM in C3H10T1/2 cells.
Physalin H

Physalin H is an inhibitor of Hedgehog (Hh) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC50 value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC50 values of 5.7 and 6.8 μM, respectively.
TAK-441 

TAK-441 is a highly potent and orally active hedgehog (Hh) signaling inhibitor with an IC50value of 4.4 nM. TAK-441 has strong antitumor activity in solid tumors.
  Catalog
Abmole Inhibitor Catalog




Keywords: Hedgehog IN-3 supplier, Hedgehog, inhibitors, activators

 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.