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Isotheaflavin

Cat. No. M40033
Isotheaflavin Structure
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Biological Activity

Isotheaflavin is one of antioxidant polyphenols in black tea.

Chemical Information
Molecular Weight 564.49
Formula C29H24O12
CAS Number 31701-93-6
Form Solid
Solubility (25°C) DMSO 90 mg/mL (ultrasonic)
Storage -20°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Oluwakemi Ebenezer et al. Acta Pharm. Promising inhibitors against main protease of SARS CoV-2 from medicinal plants: In silico identification

[2] Binxing Zhou et al. Food Chem. Impact of prolonged withering on phenolic compounds and antioxidant capability in white tea using LC-MS-based metabolomics and HPLC analysis: Comparison with green tea

[3] Martiniano Bello et al. J Biomol Struct Dyn. Elucidation of the inhibitory activity of plant-derived SARS-CoV inhibitors and their potential as SARS-CoV-2 inhibitors

[4] Chia-Nan Chen et al. Evid Based Complement Alternat Med. Inhibition of SARS-CoV 3C-like Protease Activity by Theaflavin-3,3'-digallate (TF3)

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