Free shipping on all orders over $ 500

Ishophloroglucin A

Cat. No. M18517
Ishophloroglucin A Structure
Synonym:

IPA

Size Price Availability Quantity
10mg USD 780  USD780 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?
Quality Control & Documentation
Biological Activity

Ishophloroglucin A, isolated from Ishige okamurae, is a potent PTP1B inhibitor with IC50 of 0.43 μM, inhibits adipogenesis in 3T3-L1 adipocytes.

Protocol (for reference only)
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Male CrljOri:CD1 (ICR) mice (9-week-old, 33 ± 3 g)
Formulation IPA were dissolved in saline
Dosages 2 mg/kg/day, for 28 days
Administration orally
Chemical Information
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Seung Tae Im, et al. Fitoterapia. Ishophloroglucin A, a potent PTP1B inhibitor isolated from brown alga Ishige okamurae inhibits adipogenesis in 3T3-L1 adipocytes

[2] Hye-Won Yang, et al. Mar Drugs. Ishophloroglucin A, Isolated from Ishige okamurae, Alleviates Dexamethasone-Induced Muscle Atrophy through Muscle Protein Metabolism In Vivo

[3] Xining Li, et al. Mar Drugs. Ishophloroglucin A Isolated from Ishige okamurae Suppresses Melanogenesis Induced by α-MSH: In Vitro and In Vivo

[4] Hye-Won Yang, et al. Mar Drugs. Effect of Ishophloroglucin A, A Component of Ishige okamurae, on Glucose Homeostasis in the Pancreas and Muscle of High Fat Diet-Fed Mice

[5] K H N Fernando, et al. Int J Mol Sci. Ishige okamurae Extract and Its Constituent Ishophloroglucin A Attenuated In Vitro and In Vivo High Glucose-Induced Angiogenesis

[6] BoMi Ryu, et al. Mar Drugs. Ishophloroglucin A, a Novel Phlorotannin for Standardizing the Anti-α-Glucosidase Activity of Ishige okamurae

Related Others Products
Lutonarin

Lutonarin is a antioxidant agent that can be isolated from green barley leaves. Lutonarin (Isoorientin 7-O-glucoside) is a natural product found in aerial part of Silene jeniseensis.
Ethyl glucoside

Ethyl glucoside is a kind of phenolic compound. Ethyl β-D-glucopyranoside can be isolated from ethanolic extract of Scabiosa stellata LS.
Methyl 2,4-dihydroxyphenylacetate

Methyl 2,4-dihydroxyphenylacetate is a natural product isolated from Nigella damascena seeds with selective phytotoxic effects.
Magnesium Lithospermate B

Magnesium Lithospermate B is a derivative of caffeic acid tetramer extracted from Salviae miltiorrhizae. Magnesium Lithospermate B is widely used for the research of cardiovascular diseases, and it can protect against glucose-induced intracellular oxidative damage. Magnesium Lithospermate B also suppresses neuroinflammation and attenuates neurodegeneration.
5-O-Methylvisamminol

5-O-Methylvisamminol, a (furo) chromone identified in the extract of T. glauca. 5-O-Methylvisamminol is useful in (chemical) phylogeny and is a possible excellent chemotaxonomic marker for Apiaceae.
  Catalog
Abmole Inhibitor Catalog




Keywords: Ishophloroglucin A, IPA supplier, Others, inhibitors, activators

 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.