Free shipping on all orders over $ 500

IOX2

Cat. No. M2573
IOX2 Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 65  USD65 In stock
5mg USD 70  USD70 In stock
10mg USD 100  USD100 In stock
50mg USD 400  USD400 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM, >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH. IOX2 efficiently promotes HIF-1α stability, nuclear translocation, and target gene expression in keratinocytes and fibroblasts. In addition, IOX2 significantly upregulates biosynthesis and transcription of VEGF-A and BNIP3 in sulfur mustard (SM)-exposed NHEK and NHDF grown under hypoxia.

Customer Product Validations & Biological Datas
Source Sci Rep (2017). Figure 5. IOX2
Method RT-PCR
Cell Lines Primary articular chondrocytes
Concentrations 20 μM
Incubation Time 72 hours
Results We found that expression of proliferation markers, p57 and cyclin D1, were both reduced by 28%
Chemical Information
Molecular Weight 352.34
Formula C19H16N2O5
CAS Number 931398-72-0
Solubility (25°C) DMSO 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Cheng-Bang Jian, et al. Liposomal PHD2 Inhibitors and the Enhanced Efficacy in Stabilizing HIF-1α

[2] Julianty Frost, et al. Von Hippel-Lindau (VHL) small-molecule inhibitor binding increases stability and intracellular levels of VHL protein

[3] Moses Philip, et al. Metabolic studies of hypoxia-inducible factor stabilisers IOX2, IOX3 and IOX4 (in vitro) for doping control

[4] Monica Mazzarino, et al. UPLC-MS-Based Procedures to Detect Prolyl-Hydroxylase Inhibitors of HIF in Urine

[5] Ke Peng, et al. Dexmedetomidine post-treatment attenuates cardiac ischaemia/reperfusion injury by inhibiting apoptosis through HIF-1α signalling

Related HIF Products
3-Aminobenzoic acid

3-Aminobenzoic acid is a hypoxia-inducible factor-1α (HIF-1α) inhibitor.

Steppogenin

Steppogenin is a potent inhibitor of HIF-1α and DLL4, with IC50 values of 0.56 and 8.46 μM, respectively.

HIV-IN-7

Axl-IN-16 is a Axl inhibitor.

HIF-2α-IN-9

HIF-2α-IN-9 is an inhibitor ofHIF-2α.

PHD-IN-2

PHD-IN-2 is a PHD antagonist (IC50: < 5 nM).

  Catalog
Abmole Inhibitor Catalog




Keywords: IOX2 supplier, HIF, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.