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Humantenine

Cat. No. M40087
Humantenine Structure
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Biological Activity

Humantenine is a indole alkaloid compound isolated from Gelsemium elegans.

Chemical Information
Molecular Weight 354.44
Formula C21H26N2O3
CAS Number 82375-29-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yajiao Wu et al. Genes (Basel). Effect of Humantenine on mRNA m6A Modification and Expression in Human Colon Cancer Cell Line HCT116

[2] Meng-Die Gong et al. Rapid Commun Mass Spectrom. A high-resolution mass spectrometric approach to a qualitative and quantitative comparative metabolism of the humantenine-type alkaloid rankinidine

[3] Si-Juan Huang et al. Curr Drug Metab. In vitro Metabolism of Humantenine in Liver Microsomes from Human, Pig, Goat and Rat

[4] You-Kai Xu et al. J Nat Prod. Koumine, Humantenine, and Yohimbane Alkaloids from Gelsemium elegans

[5] L Z Lin et al. J Nat Prod. New humantenine-type alkaloids from Gelsemium elegans

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