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Hesperetin 7-O-glucoside

Cat. No. M18260
Hesperetin 7-O-glucoside Structure
Size Price Availability Quantity
2mg USD 160  USD160 In stock
5mg USD 270  USD270 In stock
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Biological Activity

Hesperetin 7-O-glucoside

Chemical Information
Molecular Weight 464.42
Formula C22H24O11
CAS Number 31712-49-9
Form Solid
Solubility (25°C) DMSO 25 mg/mL
Storage 4°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mahendra P Kapoor, et al. Molecules. Structural Investigation of Hesperetin-7- O-Glucoside Inclusion Complex with β-Cyclodextrin: A Spectroscopic Assessment

[2] Fang Wu, et al. J Agric Food Chem. In Vitro and In Vivo Studies Reveal that Hesperetin-7- O-glucoside, a Naturally Occurring Monoglucoside, Exhibits Strong Anti-inflammatory Capacity

[3] Fang Wu, et al. J Agric Food Chem. Short-Term Intake of Hesperetin-7- O-Glucoside Affects Fecal Microbiota and Host Metabolic Homeostasis in Mice

[4] Wenjing Wan, et al. Front Bioeng Biotechnol. A Novel and High-Effective Biosynthesis Pathway of Hesperetin-7-O-Glucoside Based on the Construction of Immobilized Rhamnosidase Reaction Platform

[5] Lucas Actis-Goretta, et al. Mol Nutr Food Res. Gastrointestinal absorption and metabolism of hesperetin-7-O-rutinoside and hesperetin-7-O-glucoside in healthy humans

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