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GZD824

Cat. No. M2749
GZD824 Structure
Size Price Availability
5mg USD 100 4-7 Days
25mg USD 350 4-7 Days
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

GZD824 is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 724.77
Formula C29H27F3N6O.2CH4O3S
CAS Number 1421783-64-3
Purity >98%
Solubility DMSO 90 mg/mL
Storage at -20°C
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GZD824 Dimesylate

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: GZD824 supplier, Src-bcr-Abl, inhibitors

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