Certificate of Analysis

 

Product Name: GZD824 Dimesylate
Catalog Number: M2749
CAS Number: 1421783-64-3

Physical and Chemical Properties
Formula: C29H27F3N6O.2CH4O3S
Molecular Weight: 724.77
Solubility: DMSO 90 mg/mL
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: GZD824 Dimesylate Structure
Analytical Data
QC Standard: 99.30%
H-NMR: Consistent with structure
Product Information
Description: GZD824 is a third-generation oral effective BCR-ABL inhibitor, acting on BCR-ABL (WT) and BCR-ABL (T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.