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Ginsenoside Ra2

Cat. No. M40016
Ginsenoside Ra2 Structure
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Biological Activity

Ginsenoside Ra2 is a component from Panax ginseng.

Chemical Information
Molecular Weight 1211.38
Formula C58H98O26
CAS Number 83459-42-1
Form Solid
Storage 4°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Li-Juan Ma et al. J Pharm Biomed Anal. Ginsenoside distribution in different architectural components of Panax notoginseng inflorescence and infructescence

[2] Li-Juan Ma et al. J Agric Food Chem. Quantitative Characterization of Ginsenoside Biotransformation in Panax notoginseng Inflorescences and Leaves by Online Two-Dimensional Liquid Chromatography Coupled to Mass Spectrometry

[3] Qi-le Zhou et al. Zhongguo Zhong Yao Za Zhi. [Chemical constituents of Chinese red ginseng]

[4] Xin-Fang Xu et al. J Ginseng Res. Identification of mountain-cultivated ginseng and cultivated ginseng using UPLC/oa-TOF MSE with a multivariate statistical sample-profiling strategy

[5] Ho-Young Shin et al. Biol Pharm Bull. Purification and characterization of ginsenoside Ra-hydrolyzing beta-D-xylosidase from Bifidobacterium breve K-110, a human intestinal anaerobic bacterium

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