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Gentamicin Sulfate

Cat. No. M3595

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Gentamicin Sulfate Structure
Synonym:

Gentamycin Sulfate; Gentacycol

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
500mg USD 40  USD40 In stock
1g USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Gentamycin (Gentacycol) is an aminoglycoside antibiotic and was isolated from Micromonospora species. Gentamicin sulfate is a strong inhibitor of DNase I with an IC50 value of 0.57 ± 0.12 mM. It is a broad-spectrum cell culture antibiotic that is nontoxic to viruses and mammalian cells at antibacterial and antimycoplasmal concentrations. Its extended stability and slow development of bacterial resistance allow long-term virus and tissue culture studies. It is not used for Neisseria gonorrhoeae, Neisseria meningitidis or Legionella pneumophila bacterial infections (because of the risk of the patient going into shock from lipid A endotoxin found in certain Gram-negative organisms). Gentamicin is also useful against Yersinia pestis and its relatives although need for treatment in most cases is rare, as this bacterium is the one that causes plague.

Product Citations
Chemical Information
Molecular Weight 575.67
Formula C21H43N5O7.H2SO4
CAS Number 1405-41-0
Solubility (25°C) Water 25 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Wei Xu, et al. Anal Bioanal Chem . A rapid and sensitive method for kinetic study and activity assay of DNase I in vitro based on a GO-quenched hairpin probe

[2] Espersen F, et al. Antimicrob Agents Chemother. Effect of treatment with methicillin and gentamicin in a new experimental mouse model of foreign body infection.

[3] Rudin A, et al. Appl Microbiol. Antibacterial activity of gentamicin sulfate in tissue culture.

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Keywords: Gentamicin Sulfate, Gentamycin Sulfate; Gentacycol supplier, Animal Modeling, inhibitors, activators

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