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γ-Mangostin

Cat. No. M17903
γ-Mangostin Structure
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Biological Activity

γ-Mangostin

Chemical Information
CAS Number 31271-07-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sih-Pei Chen, et al. Biomed Pharmacother. Mangosteen xanthone γ-mangostin exerts lowering blood glucose effect with potentiating insulin sensitivity through the mediation of AMPK/PPARγ

[2] Rifa'atul Mahmudah, et al. J Adv Pharm Technol Res. Molecular docking studies of α-mangostin, γ-mangostin, and xanthone on peroxisome proliferator-activated receptor gamma diphenyl peptidase-4 enzyme, and aldose reductase enzyme as an antidiabetic drug candidate

[3] Ji Yun Baek, et al. Biomolecules. Protective Effect of γ-mangostin Isolated from the Peel of Garcinia mangostana against Glutamate-Induced Cytotoxicity in HT22 Hippocampal Neuronal Cells

[4] Balaji Krishnamachary, et al. Oncotarget. Targeting transcription factor TCF4 by γ-Mangostin, a natural xanthone

[5] Yamaratee Jaisin, et al. Neurosci Lett. Protective effects of γ-mangostin on 6-OHDA-induced toxicity in SH-SY5Y cells

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