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Floxuridine

Cat. No. M5648

Floxuridine Structure

Synonym: Deoxyfluorouridine, FDUR, NSC 27640

Size Price Availability Quantity
100mg USD 120 In stock
500mg USD 300 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Floxuridine is an antineoplastic antimetabolite, used in the treatment of colon carcinoma and colorectal cancer that has metastasized to the liver.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 246.19
Formula C9H11FN2O5
CAS Number 50-91-9
Purity >99%
Solubility 49 mg/mL in DMSO
Storage at -20°C
References

Synthesis and in vitro evaluation of bile acid prodrugs of floxuridine to target the liver.
Vivian D, et al. Int J Pharm. 2014 Nov 20;475(1-2):597-604. PMID: 25219859.

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Keywords: Floxuridine, Deoxyfluorouridine, FDUR, NSC 27640 supplier, DNA/RNA Synthesis, inhibitors

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