Evodol is a natural product isolated from the dried and nearly ripe fruits of Euodia rutaecarpa. Evodol shows inhibitory activity against NO production. Evodol possesses larvicidal activity against the Asian tiger mosquitoes with a LC50 value of 32.43 μg/ml.
| Molecular Weight | 484.5 |
| Formula | C26H28O9 |
| CAS Number | 22318-10-1 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Jie Zhao et al. Xenobiotica. Mechanism-based inactivation of cytochrome P450 3A by evodol
[5] Y HIROSE. Chem Pharm Bull (Tokyo). The structure of evodol, a principle of Evodia rutaecarpa
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