EP6 is a potent 5-Lipoxygenase (5-LO) inhibitor.
| Molecular Weight | 390.52 |
| Formula | C24H30N4O |
| CAS Number | 1353567-32-4 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Yu-Yan Chen et al. Anal Biochem. A chemiluminescence immunoassay for the detection of NT-proBNP
| Related Lipoxygenase Products |
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| ALOX15-IN-2
ALOX15-IN-2 is a potent inhibitor of rabbit and human ALOX15 linoleate oxygenase activity, with IC50s of 1.55 and 2.79 μM for linoleic acid (LA) and arachidonic acid (AA), the immediate homologs of ALOX15, respectively. |
| Atractylochromene
Atractylochromene is a potent dual inhibitor of 5-LOX/COX-1 with IC50s of 0.6 and 3.3 μM, respectively. |
| 5-LOX-IN-5
5-LOX-IN-5 is a 5-LOX inhibitor (IC50: 56 nM). |
| Patulitrin
Patulitrin has scavenging effect in the DPPH radical. |
| 5-LOX-IN-3
5-LOX-IN-3 is a 5-Lipoxygenase inhibitor (IC50: <1 μM). |
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