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Abmole Inhibitor Catalog 2017

Lipoxygenase 5-lipoxygenase-activating protein (FLAP)

Inhibitors

Cat.No.  Name Information
M3728 MK 886 MK 886 is a potent 5-lipoxygenase activating protein inhibitor (FLAP) (IC50 = 44 nM).
M2733 GSK2190915 GSK2190915 (AM803), a potent FLAP inhibitor, prevents the synthesis of leukotrienes and 5-oxo-ETE, with IC50 of 76 nM for inhibition of LTB4 in human blood, provides treatment for asthma.
M2332 Zileuton Zileuton is an orally active 5-lipoxygenase (5-LOX) inhibitor that inhibits LTB4 synthesis with IC50 values of 0.56, 2.3 and 2.6 μM in dog, rat and human blood respectively.


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