Malotilate is a hepatoprotective agent used in the treatment of liver disease. Malotilate accelerates the recovery of impaired protein metabolism in alcoholic liver disease. It has been shown to facilitate liver regeneration in rats.
Molecular Weight | 288.38 |
Formula | C12H16O4S2 |
CAS Number | 59937-28-9 |
Form | Solid |
Solubility (25°C) | DMSO 50 mg/mL Ethanol 50 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Y Matsuda, et al. Effects of malotilate on alcoholic liver injury in rats
[4] S Takase, et al. Effects of malotilate treatment on alcoholic liver disease
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