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GSK2190915

Cat. No. M2733
GSK2190915 Structure
Synonym:

AM-803, Fiboflapon

Size Price Availability
5mg USD 140 Out of stock
25mg USD 460 Out of stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

GSK2190915 (AM803), a potent FLAP inhibitor, prevents the synthesis of leukotrienes and 5-oxo-ETE, with IC50 of 76 nM for inhibition of LTB4 in human blood, provides treatment for asthma.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 637.83
Formula C38H43N3O4S
CAS Number 936350-00-4
Purity >99%
Solubility DMSO
Storage at -20°C
Related Lipoxygenase Products
MK 886

MK 886 is a potent 5-lipoxygenase activating protein inhibitor (FLAP) (IC50 = 44 nM).

Zileuton

Zileuton is an orally active 5-lipoxygenase (5-LOX) inhibitor that inhibits LTB4 synthesis with IC50 values of 0.56, 2.3 and 2.6 μM in dog, rat and human blood respectively.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: GSK2190915, AM-803, Fiboflapon supplier, Lipoxygenase, inhibitors

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