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Eleutheroside C

Cat. No. M40009
Eleutheroside C Structure
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Biological Activity

Eleutheroside C (Ethyl α-D-galactoside) is a glycoside isolated from the bulbs of Polianthes tuberosa.

Chemical Information
Molecular Weight 208.21
Formula C8H16O6
CAS Number 15486-24-5
Form Solid
Storage 4°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Shangfan Sun et al. Hum Exp Toxicol. Mitochondrial dysfunction is involved in the cellular activity inhibition by eleutheroside B in SMMC-7721 and HeLa cells

[2] Mengyao Liu et al. J Sci Food Agric. Eleutheroside E reduces intestinal fat accumulation in Caenorhabditis elegans through neuroendocrine signals

[3] Hai-Yue Lan et al. J Ethnopharmacol. Aidi injection induces apoptosis of hepatocellular carcinoma cells through the mitochondrial pathway

[4] Mengyao Liu et al. J Nat Prod. Eleutheroside E Enhances the Long-Term Memory of Radiation-Damaged C. elegans through G-Protein-Coupled Receptor and Neuropeptide Signaling Pathways

[5] Yun-Seo Kil et al. Arch Pharm Res. Utilization of circular dichroism experiment to distinguish acanthoside D and eleutheroside E

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