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D-(+)-Cellotetraose

Cat. No. M39964
D-(+)-Cellotetraose Structure
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Biological Activity

D-(+)-Cellotetraose (Cellotetraose) is a primary hydrolysis product of cellulose.

Chemical Information
Molecular Weight 666.58
Formula C24H42O21
CAS Number 38819-01-1
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yuko Yoneda et al. J Am Chem Soc. Van der Waals versus hydrogen-bonding forces in a crystalline analog of cellotetraose: cyclohexyl 4'-O-cyclohexyl beta-D-cellobioside cyclohexane solvate

[2] K Gessler et al. Science. Crystal structure of beta-D-cellotetraose hemihydrate with implications for the structure of cellulose II

[3] B J Poppleton et al. Nature. Crystal structure of beta-D-cellotetraose and its relationship to cellulose

[4] M E Himmel et al. J Biol Chem. Isolation and characterization of a 1,4-beta-D-glucan glucohydrolase from the yeast, Torulopsis wickerhamii

[5] H Hatakeyama et al. Carbohydr Res. Studies on the isothermal crystallization of D-glucose and cellulose oligosaccharides by differential scanning calorimetry

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