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Catenarin

Cat. No. M19351
Catenarin Structure
Size Price Availability Quantity
5mg USD 250  USD250 In stock
10mg USD 450  USD450 In stock
20mg USD 650  USD650 In stock
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Biological Activity

Catenarin

Chemical Information
Formula C29H36O15
CAS Number 476-46-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Miquel Martorell, et al. Evid Based Complement Alternat Med. An Update of Anthraquinone Derivatives Emodin, Diacerein, and Catenarin in Diabetes

[2] Shih-Chang Chien, et al. Evid Based Complement Alternat Med. Naturally occurring anthraquinones: chemistry and therapeutic potential in autoimmune diabetes

[3] Ming-Yi Shen, et al. Evid Based Complement Alternat Med. Catenarin Prevents Type 1 Diabetes in Nonobese Diabetic Mice via Inhibition of Leukocyte Migration Involving the MEK6/p38 and MEK7/JNK Pathways

[4] W K Anslow, et al. Biochem J. Studies in the biochemistry of micro-organisms: Synthesis of catenarin (1:4:5:7-tetrahydroxy-2-methylanthraquinone), a metabolic product of species of Helminthosporium

[5] H Raistrick, et al. Biochem J. Studies in the biochemistry of micro-organisms: (a) On the production of hydroxyanthraquinones by species of Helminthosporium. (b) Isolation of tritisporin, a new metabolic product of Helminthosporium tritici-vulgaris Nisikado. (c) The molecular constitut䲧盷Ỵ相㧀盶羹甗

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