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Blinin

Cat. No. M19446
Blinin Structure
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Biological Activity

Blinin is a neoclerodane diterpene, isolated from the whole plant of Conyza blinii.

Chemical Information
Molecular Weight 392.49
Formula C22H32O6
CAS Number 125675-09-4
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Cline Vergne, et al. Bull Cancer. [Transition to adulthood: An essential period in the follow up of young patients]

[2] Clara Sortais, et al. Ann Hematol. Progression of disease within 2 years (POD24) is a clinically relevant endpoint to identify high-risk follicular lymphoma patients in real life

[3] Olivier Bluteau, et al. Blood. A landscape of germ line mutations in a cohort of inherited bone marrow failure patients

[4] Rikkert L Snoeckx, et al. Am J Hum Genet. GJB2 mutations and degree of hearing loss: a multicenter study

[5] C Welter, et al. Dtsch Med Wochenschr. [Tumor suppressor genes]

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