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Bellidifolin

Cat. No. M17914
Bellidifolin Structure
Size Price Availability Quantity
5mg USD 260  USD260 In stock
10mg USD 360  USD360 In stock
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Quality Control & Documentation
Biological Activity

Bellidifolin

Chemical Information
CAS Number 2798-25-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ting-Ting Yao, et al. Evid Based Complement Alternat Med. Bellidifolin Inhibits SRY-Related High Mobility Group-Box Gene 9 to Block TGF- β Signalling Activation to Ameliorate Myocardial Fibrosis

[2] Hong-Xia Yang, et al. Front Pharmacol. Bellidifolin Ameliorates Isoprenaline-Induced Myocardial Fibrosis by Regulating TGF-β1/Smads and p38 Signaling and Preventing NR4A1 Cytoplasmic Localization

[3] Li Yan, et al. J Oncol. Bellidifolin Inhibits Proliferation of A549 Cells by Regulating STAT3/COX-2 Expression and Protein Activity

[4] Zhi-Ying Zhao, et al. J Toxicol Environ Health A. Protective effects of bellidifolin in hypoxia-induced in pheochromocytoma cells (PC12) and underlying mechanisms

[5] P Basnet, et al. Planta Med. Bellidifolin: a potent hypoglycemic agent in streptozotocin (STZ)-induced diabetic rats from Swertia japonica

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