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Azedarachol

Cat. No. M40092
Azedarachol Structure
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Biological Activity

Azedarachol possesses antifeedant activity.

Chemical Information
Molecular Weight 420.58
Formula C25H40O5
CAS Number 99305-11-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] R Khaldi et al. Trop Biomed. Phytochemical composition of almond oil from Melia azedarach L. and its larvicidal, ovicidal, repellent and enzyme activities in Culex pipiens L

[2] Lei Feng et al. Sci Rep. Predicting suitable habitats of Melia azedarach L. in China using data mining

[3] Min Song et al. Phytochemistry. Triterpenoids from the fruits of Melia azedarach L. and their cytotoxic activities

[4] Godfried Dougnon et al. J Nat Med. Essential oils from Melia azedarach L. (Meliaceae) leaves: chemical variability upon environmental factors

[5] Won Hyung Choi et al. Asian Pac J Trop Biomed. The anti-tubercular activity of Melia azedarach L. and Lobelia chinensis Lour. and their potential as effective anti- Mycobacterium tuberculosis candidate agents

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