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Arjungenin

Cat. No. M40094
Arjungenin Structure
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Biological Activity

Arjungenin, a triterpene isolated from Terminalia arjuna, is an insect feeding-deterrent and growth inhibitor.

Chemical Information
Molecular Weight 504.7
Formula C30H48O6
CAS Number 58880-25-4
Form Solid
Solubility (25°C) DMSO 50 mg/mL (ultrasonic)
Storage 4°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Rajesh Kumar Verma et al. Nat Prod Res. Novel extraction technique: quantification of major phytoconstituents of arjuna in infused edible oil

[2] Mohan Manu T et al. Comput Biol Chem. In-silico therapeutic investigations of arjunic acid and arjungenin as an FXR agonist and validation in 3T3-L1 adipocytes

[3] Alice Varghese et al. Toxicol Rep. In vitro modulatory effects of Terminalia arjuna, arjunic acid, arjunetin and arjungenin on CYP3A4, CYP2D6 and CYP2C9 enzyme activity in human liver microsomes

[4] Alice Varghese et al. Indian J Pharm Sci. In vitro and in vivo Evaluation of CYP1A Interaction Potential of Terminalia Arjuna Bark

[5] R S Pawar et al. Phytomedicine. Effect of oleanane triterpenoids from Terminalia arjuna--a cardioprotective drug on the process of respiratory oxyburst

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