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6-Deoxyjacareubin

Cat. No. M17898
6-Deoxyjacareubin Structure
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Biological Activity

6-Deoxyjacareubin

Chemical Information
CAS Number 16265-56-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Tomonori Hoshino, et al. Neurosci Res. 6-Deoxyjacareubin, a natural compound preventing hypoxia-induced cell death, ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis

[2] Bo Yi, et al. Molecules. Antioxidant phenolic compounds of cassava (Manihot esculenta) from Hainan

[3] Dai-Jing Wei, et al. J Asian Nat Prod Res. A new prenylated xanthone from the branches of Calophyllum inophyllum

[4] Hisae Oku, et al. Planta Med. Inhibitory effects of xanthones from guttiferae plants on PAF-induced hypotension in mice

[5] A C Doriguetto, et al. Acta Crystallogr C. 6-Deoxyjacareubin

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