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17-DMAG hydrochloride

Cat. No. M2321
17-DMAG hydrochloride Structure
Synonym:

Alvespimycin, NSC 707545

Size Price Availability Quantity
25mg USD 110 In stock
100mg USD 280 In stock
200mg USD 440 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

17-DMAG hydrochloride (Alvespimycin), a watersoluble geldanamycin analog belonging to the class of benzoquinones, is a selective Hsp90 inhibitor. 17-DMAG hydrochloride binds to the N-terminal domain ATP binding site of Hsp90, inhibiting Hsp90 chaperone activity. 17-DMAG hydrochloride demonstrates greater potency and water solubility than other geldanamycin analogs such as 17-AAG (mean GI50 values are 53 and 123 nM for 17-DMAG hydrochloride and 17-AAG respectively), while demonstrating anti-tumor activity and offering excellent oral bioavailability.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 653.21
Formula C32H48N4O8.HCl
CAS Number 467214-21-7
Purity >99%
Solubility DMSO 100 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: 17-DMAG hydrochloride, Alvespimycin, NSC 707545 supplier, HSP90, inhibitors

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