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10-Hydroxy majoroside

Cat. No. M39948
10-Hydroxy majoroside Structure
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Biological Activity

10-Hydroxy majoroside is a methanol extract isolated from plantago asiatica.

Chemical Information
Molecular Weight 404.37
Formula C17H24O11
CAS Number 259753-12-3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ruixin Li et al. J Pharm Sci. Encapsulation of 10-hydroxy camptothecin in supramolecular hydrogel as an injectable drug delivery system

[2] Ursula Breyer-Pfaff. Drug Metab Rev. The metabolic fate of amitriptyline, nortriptyline and amitriptylinoxide in man

[3] K L Thompson et al. Drug Metab Dispos. Metabolism of kadsurenone and 9,10-dihydrokadsurenone in rhesus monkeys and rat liver microsomes

[4] R E McCue. Clin Geriatr Med. Using tricyclic antidepressants in the elderly

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