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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M1767 | R-406 | R406 is an orally bioavailable and selective inhibitor of spleen tyrosine kinase (Syk) with the IC50 of 41nM and Ki value of 30 nM. |
| M20799 | GS-9876 (lanraplenib) | Lanraplenib (GS-9876, GS-SYK) is a potent, highly selective and orally active inhibitor of Spleen Tyrosine Kinase (SYK) with IC50 of 9.5 nM. Lanraplenib inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans. |
| M20797 | SRX3207 | SRX3207 is an orally active dual inhibitor of Syk-PI3K with IC50 of 39.9 nM, 31200 nM, 3070 nM, 3070 nM, 244 nM, 388 nM, 9790 nM for Syk, Zap70, BRD41, BRD42, PI3K alpha, PI3K delta, PI3K gamma, respectively. SRX3207 blocks tumor immunosuppression and increases anti-tumor immunity. |
| M20593 | RO9021 | RO9021 potently inhibits SYK kinase activity with an average IC50 of 5.6 nM and suppresses B-cell receptor signaling. |
| M20371 | WAY-321341 | WAY-321341 is a syk inhibitor |
| M20069 | WAY-299721 | WAY-299721 is a impede the interaction of Syk with its cellular partners while maintaining an active kinase protein (Syk inhibitor) |
| M14917 | Fostamatinib disodium hexahydrate | Fostamatinib (R788) disodium hexahydrate is the oral prodrug of the active compound R406. |
| M14916 | R406 besylate | R406 is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM, measured at an ATP concentration corresponding to its Km value. |
| M14915 | Cerdulatinib hydrochloride | Cerdulatinib hydrochloride (PRT062070) is a selective, oral active and reversible ATP-competitive inhibitor of dual SYK and JAK, with IC50s of 32 nM, 0.5 nM, 12 nM, 6 nM and 8 nM for SYK and Tyk2, JAK1, 2, 3, respectively. |
| M10688 | TAK-659 | TAK-659 hydrochloride is a highly selective, reversible, orally potent dual inhibitor of SYK/FLT3 that acts on SYK and FLT3 IC50 The values are 3.2 nM and 4.6 nM, respectively. TAK-659 hydrochloride induces tumor cell death without acting on non-tumor cells, with potential to study chronic lymphocytic leukemia (CLL). |
| M9012 | R112 | R112 is an ATP-competitive inhibitor of Syk kinase with an IC50 of 226 nM. |
| M5252 | PRT-060318 | PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment. |
| M5247 | BAY 61-3606 dihydrochloride | BAY-61-3606 is a potent and selective inhibitor of Syk kinase (Ki = 7.5 nM). |
| M2941 | Piceatannol | Piceatannol, a natural stilbene, is a selective Syk inhibitor and ~10-fold selectivity versus Lyn. |
| M2729 | GS-9973 | GS-9973 is an orally bioavailable, selective Syk inhibitor with IC50 of 7.7 nM. |
| M2063 | P505-15 hydrochloride | P505-15 (PRT062607) is a novel, highly selective inhibitor of Syk with IC50 value of 1-2 nM. |
| M1990 | Fostamatinib (R788) | R788 (Fostamatinib) is a spleen tyrosine kinase (Syk) inhibitor with IC50 of 41 nM. |
| M1847 | Fostamatinib disodium | Fostamatinib disodium (R788, R-935788) is a potent, ATP-competitive and selective Syk (Spleen tyrosine kinase) inhibitor with IC50 of 41 nM. |
| M1767 | R-406 | R406 is an orally bioavailable and selective inhibitor of spleen tyrosine kinase (Syk) with the IC50 of 41nM and Ki value of 30 nM. |
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