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GS-9973

Cat. No. M2729
GS-9973 Structure
Synonym:

Entospletinib

Size Price Availability Quantity
10mg USD 120 In stock
50mg USD 420 In stock
100mg USD 680 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

GS-9973 is an orally bioavailable, selective Syk inhibitor with IC50 of 7.7 nM, which is currently undergoing clinical evaluation for autoimmune and oncology indications.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 411.46
Formula C23H21N7O
CAS Number 1229208-44-9
Purity >99%
Solubility DMSO 60 mg/mL
Storage at -20°C
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Piceatannol

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P505-15 hydrochloride

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R788

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: GS-9973, Entospletinib supplier, Syk, inhibitors

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