Free shipping on all orders over $ 500

Piceatannol

Cat. No. M2941
Piceatannol Structure
Synonym:

Astringenin

Size Price Availability Quantity
25mg USD 140 In stock
50mg USD 210 In stock
Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Piceatannol is a selective Syk inhibitor with IC50 of ~10 μM. Piceatannol is a plant secondary natural product which inhibits the purified thymocyte p40 kinase (the catalytic fragment of Syk), by competing for the peptide or protein substrate binding site with Ki of 15 μM. Piceatannol also inhibits the activity of the p56lck protein-tyrosine kinase in LSTRA cell membranes or intact cells. Piceatannol preferentially inhibits the activity of Syk in comparison to Lyn in in vitro kinase assays. Selective inhibition of Syk by Piceatannol blocks receptor-mediated down-stream cellular responses (inositol 1,4,5-trisphosphate production, secretion, ruffling, and spreading). Piceatannol is a potent inducer of apoptosis in the lymphoma cell line BJAB by causing a concentration-dependent activation of caspase-3 and mitochondrial permeability transition. Piceatannol but not resveratrol is a very efficient inducer of apoptosis in ex vivo assay with leukemic lymphoblasts of 21 patients suffering from childhood lymphoblastic leukemia (ALL). Piceatannol inhibits TNF-induced NF-κB activation and NF-κB-mediated gene expression through suppression of IκBα kinase and p65 phosphorylation. Piceatannol inhibits the growth of colorectal cancer cell lines and arrests Caco-2 cells in the S phase of the cell cycle. Sequential treatment with Piceatannol and Ara-C yields synergistic growth inhibitory effects against HL-60 cells because of remarkably increased Ara-CTP formation after Piceatannol preincubation. Exposure of different-stage PC-3 prostate cancer (CaP) cells to Piceatannol also results in cell-type-specific downregulation of mTOR and its upstream and downstream effector proteins, AKT and eIF-4E-BP1.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 244.24
Formula C14H12O4
CAS Number 10083-24-6
Purity >99%
Solubility DMSO 30 mg/mL
Storage at -20°C
Related Syk Products
PRT-060318

PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment.

BAY-61-3606

BAY-61-3606 is a potent and selective inhibitor of Syk kinase (Ki = 7.5 nM).

GS-9973

GS-9973 is an orally bioavailable, selective Syk inhibitor with IC50 of 7.7 nM.

P505-15 hydrochloride

P505-15 (PRT062607) is a novel, highly selective inhibitor of Syk with IC50 value of 1-2 nM.

R788

R788 (Fostamatinib) is a spleen tyrosine kinase (Syk) inhibitor with IC50 of 41 nM.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Piceatannol, Astringenin supplier, Syk, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.