|M11262||MHP||MHP (Methyl caprooyl tyrosinate), an activator of sphingosine kinase (SPHK1), can significantly increase CAMP mRNA and protein levels. MHP (Methyl caprooyl Tyrosinate) can enhance anti-microbial defense and innate immunity.|
|M11034||Netarsudil (AR-13324) 2HCl||Netarsudil (AR-13324) is a ROCK inhibitor with a Ki value of 0.2-10.3 nM.|
|M10599||PF-543 HCl||PF-543 hydrochloride is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 hydrochloride is >100-fold selectivity for SPHK1 over SPHK2.|
|M3719||K145 hydrochloride||K145 Hydrochloride is a selective, substrate competitive and oral inhibitor of SphK2, IC50 4.3 µM and Ki 6.4 µM. K145 hydrochloride has no activity against SphK1 and other protein kinases. K145 Hydrochloride induces apoptosis and has strong anti-tumor activity.|
|M2930||PF-543||PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM, exhibits >100-fold selectivity over the SphK2 isoform.|
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