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MHP

Cat. No. M11262
MHP Structure
Synonym:

Methyl caprooyl tyrosinate

Size Price Availability Quantity
5mg USD 135  USD135 In stock
10mg USD 240  USD240 In stock
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Quality Control & Documentation
Biological Activity

MHP (Methyl caprooyl tyrosinate), an activator of sphingosine kinase (SPHK1), can significantly increase CAMP mRNA and protein levels. MHP (Methyl caprooyl Tyrosinate) can enhance anti-microbial defense and innate immunity.

Chemical Information
Molecular Weight 293.36
Formula C16H23NO4
CAS Number 1104874-94-3
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jin Jin, et al. Front Microbiol. A Novel Lipoate-Protein Ligase, Mhp-LplJ, Is Required for Lipoic Acid Metabolism in Mycoplasma hyopneumoniae

[2] Rong Chen, et al. Front Cell Infect Microbiol. Featured Species-Specific Loops Are Found in the Crystal Structure of Mhp Eno, a Cell Surface Adhesin From Mycoplasma hyopneumoniae

[3] Julia Velten, et al. BMC Public Health. Lifestyle choices and mental health: a longitudinal survey with German and Chinese students

[4] Sensen Lin, et al. Phytomedicine. MHP-1 inhibits cancer metastasis and restores topotecan sensitivity via regulating epithelial-mesenchymal transition and TGF-β signaling in human breast cancer cells

[5] W B Hanley. Mol Genet Metab. Non-PKU mild hyperphenylalaninemia (MHP)--the dilemma

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  Catalog
Abmole Inhibitor Catalog




Keywords: MHP, Methyl caprooyl tyrosinate supplier, SPHK, inhibitors, activators


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