Catalog

Sodium Channel Sodium Channel

Inhibitors

Cat.No.	Name	Information
M10492	Ropivacaine	Ropivacaine is a member of the amino amide class of local anesthetics and acts as a potent sodium channel blocker.
M10470	Raxatrigine hydrochloride	Raxatrigine hydrochloride (GSK-1014802 hydrochloride) is a selective, small-molecule, state-dependent Nav1.7 voltage-gated sodium channel blocker.
M10458	Huwentoxin IV TFA	Huwentoxin IV TFA is a selective NaV1.7 channel blocker, which preferentially inhibits neuronal NaV1.7, 1.2 and 1.3 (IC50 values are 26, 150 and 338 nM respectively), compared to muscle subtypes NaV1.4 and 1.5 (IC50 = >10 μM).
M10113	BI01383298	BI01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5).
M9129	GNE-131	GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM.
M9115	PF-06869206	PF-06869206 is an orally bioavailable selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1) with an IC50 of 380 nM.
M9103	Eleclazine hydrochloride	Eleclazine HCl is a novel late Na+ current inhibitor, with IC50 value of 0.7 uM.
M9018	Levobupivacaine	Levobupivacaine is a reversible neuronal sodium channel inhibitor.
M8988	PF-05089771	PF-05089771 is a selective Nav1.7 channel blocker that interacts with the voltage-sensor domain (VSD) of domain IV.
M8947	PF-01247324	PF-01247324 is a novel selective and orally bioavailable Nav 1.8 channel blocker with an IC50 of 196 nM for recombinant human Nav1.8 channel.
M8911	GS967	GS967, also known as GS-458967, is a potent and selective blocker of cardiac late sodium current (late I_Na) with IC50 values of 0.13 and 0.21 μM for ventricular myocytes and isolated hearts, respectively.
M8510	Cariporide	Cariporide is a selective inhibitor of the Na+/H+ exchanger subtype 1 (NHE-1), also known as the Na+/H+ antiporter.
M8092	PF-05089771 Tosylate	PF-05089771 Tosylate is a selective and potent inhibitor of the human voltage-gated sodium ion channel Nav1.
M7572	Tenapanor	Tenapanor is an inhibitor of the Na+/H+ exchanger NHE3 with IC50 values of 5 and 10 nM against human and Rat NHE3, respectively.
M7552	ETH2120	Sodium ionophore III (ETH2120) is a Na+ ionophore suitable for the assay of sodium activity in blood, plasma, serum. etc.
M7520	Brivaracetam	Brivaracetam (UCB 34714) is chemically related to levetiracetam (LEV, Keppra). It possesses a binding affinity for the synaptic vesicle protein 2A (SV2A) ten-fold above that of LEV and also shows an ability to inhibit Na+ channels.
M6085	GSK-1014802	CNV1014802(GSK-1014802) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor.
M6068	Zonisamide	Zonisamide is a voltage-dependent sodium channel and T-type calcium channel blocker, used as an antiepileptic drug.
M6054	Vinpocetine	Vinpocetine is a selective inhibitor of voltage-sensitive sodium channel for the treatment of stroke, vascular dementia and Alzheimer's disease.
M6006	Tetracaine	Tetracaine is a topical local anesthetic for the eyes; works by interfering with entry of sodium ions into nerve cells.
M5943	Rufinamide	Rufinamide is a voltage-gated sodium channel blocker, used an anticonvulsant medication.
M5904	Proparacaine HCl	Proparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.
M5899	Procaine	Procaine is a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. *The compound is unstable in solutions, freshly prepared is recommended
M5897	Prilocaine	Prilocaine is a local anesthetic of the amino amide type. It acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation.
M5876	Phenytoin Sodium	Phenytoin Sodium is an inactive voltage-gated sodium channel stabilizer.
M5875	Phenytoin	Phenytoin is an inactive voltage-gated sodium channel stabilizer.
M5699	Ibutilide fumarate	Ibutilide Fumarate is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells.
M5603	Dyclonine HCl	Dyclonine HCl is a hydrochloride salt form of dyclonine which is an oral anaesthetic, reversibly binds to activated sodium channels on the neuronal membrane, thereby decreasing the neuronal membrane's permeability to sodium ions, leading to an increased threshold for excitation.
M5570	Dibucaine	Dibucaine is a local anesthetic of the amide type now generally used for surface anesthesia.
M5449	Benzocaine hydrochloride	Benzocaine hydrochloride is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
M5069	S0859	S0859 is an N-cyanosulphonamide compound, reversibly inhibit NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM).
M3935	Digoxin	Digoxin is widely used in the treatment of various heart conditions, namely atrial fibrillation, atrial flutter and sometimes heart failure that cannot be controlled by other medication.
M3412	Propafenone hydrochloride	Propafenone hydrochloride is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.
M3366	Amiloride hydrochloride dihydrate	Amiloride hydrochloride dihydrate is a potent epithelial sodium channel blocker.
M3358	Procainamide hydrochloride	Procainamide hydrochloride is a sodium channel blocker, and also a DNA methyltransferase inhibitor.
M3354	Carbamazepine	Carbamazepine (Carbatrol) is a sodium channel blocker with IC50 of 131 μM in rat brain synaptosomes.
M3345	Primidone	Primidone is an anticonvulsant of the pyrimidinedione class.
M3083	Triamterene	Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner with IC50 of 4.5 μM.
M2989	Ropivacaine hydrochloride monohydrate	Ropivacaine hydrochloride monohydrate is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.
M2961	Procaine hydrochloride	Procaine is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with K_D of 1.7 μM.
M2904	Ouabain	Ouabain is a selective Na+/K+, -ATPase inhibitor, binds to α2 /α3 subunit with K_i of 41 nM/15 nM.
M2802	Lamotrigine	Lamotrigine is a novel anticonvulsant compound for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, and also is a sodium channel blocker.
M2632	Dibucaine hydrochloride	Dibucaine hydrochloride is a local anesthetics.
M2530	Clopamide	Clopamide is an orally active thiazide-like diuretic agent that inhibits the sodium-coupled chloride cotransporter SLC12A3.
M2487	Camostat Mesilate	Camostat is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trpsin, prostasin and matriptase.
M2380	Ambroxol hydrochloride	AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM.
M2264	Oxcarbazepine	Oxcarbazepine is an anticonvulsant and mood-stabilizing compound.
M2210	A-803467	A-803467 is a potent and selective Nav1.8 sodium channel blocker that potently blocks tetrodotoxin-resistant currents (IC50 = 140 nM).
M1968	Riluzole	Riluzole (Rilutek) is a sodium channel protein inhibitor and novel psychotropic agent with anticonvulsant, hypnotic, anxiolytic, anti-ischemic and anesthetic properties.
M1427	Lacosamide	Lacosamide is a medication developed for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain.

Signaling Pathways

Product Type

Sodium Channel Sodium Channel

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