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Abmole Inhibitor Catalog 2017

Sodium Channel Sodium Channel


Cat.No.  Name Information
M10492 Ropivacaine Ropivacaine is a member of the amino amide class of local anesthetics and acts as a potent sodium channel blocker.
M10470 Raxatrigine hydrochloride Raxatrigine hydrochloride (GSK-1014802 hydrochloride) is a selective, small-molecule, state-dependent Nav1.7 voltage-gated sodium channel blocker.
M10458 Huwentoxin IV TFA Huwentoxin IV TFA is a selective NaV1.7 channel blocker, which preferentially inhibits neuronal NaV1.7, 1.2 and 1.3 (IC50 values are 26, 150 and 338 nM respectively), compared to muscle subtypes NaV1.4 and 1.5 (IC50 = >10 μM).
M10113 BI01383298 BI01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5).
M9129 GNE-131 GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM.
M9115 PF-06869206 PF-06869206 is an orally bioavailable selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1) with an IC50 of 380 nM.
M9103 Eleclazine hydrochloride Eleclazine HCl is a novel late Na+ current inhibitor, with IC50 value of 0.7 uM.
M9018 Levobupivacaine Levobupivacaine is a reversible neuronal sodium channel inhibitor.
M8988 PF-05089771 PF-05089771 is a selective Nav1.7 channel blocker that interacts with the voltage-sensor domain (VSD) of domain IV.
M8947 PF-01247324 PF-01247324 is a novel selective and orally bioavailable Nav 1.8 channel blocker with an IC50 of 196 nM for recombinant human Nav1.8 channel.
M8911 GS967 GS967, also known as GS-458967, is a potent and selective blocker of cardiac late sodium current (late INa) with IC50 values of 0.13 and 0.21 μM for ventricular myocytes and isolated hearts, respectively.
M8510 Cariporide Cariporide is a selective inhibitor of the Na+/H+ exchanger subtype 1 (NHE-1), also known as the Na+/H+ antiporter.
M8092 PF-05089771 Tosylate PF-05089771 Tosylate is a selective and potent inhibitor of the human voltage-gated sodium ion channel Nav1.
M7572 Tenapanor Tenapanor is an inhibitor of the Na+/H+ exchanger NHE3 with IC50 values of 5 and 10 nM against human and Rat NHE3, respectively.
M7552 ETH2120 Sodium ionophore III (ETH2120) is a Na+ ionophore suitable for the assay of sodium activity in blood, plasma, serum. etc.
M7520 Brivaracetam Brivaracetam (UCB 34714) is chemically related to levetiracetam (LEV, Keppra). It possesses a binding affinity for the synaptic vesicle protein 2A (SV2A) ten-fold above that of LEV and also shows an ability to inhibit Na+ channels.
M6085 GSK-1014802 CNV1014802(GSK-1014802) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor.
M6068 Zonisamide Zonisamide is a voltage-dependent sodium channel and T-type calcium channel blocker, used as an antiepileptic drug.
M6054 Vinpocetine Vinpocetine is a selective inhibitor of voltage-sensitive sodium channel for the treatment of stroke, vascular dementia and Alzheimer's disease.
M6006 Tetracaine Tetracaine is a topical local anesthetic for the eyes; works by interfering with entry of sodium ions into nerve cells.
M5943 Rufinamide Rufinamide is a voltage-gated sodium channel blocker, used an anticonvulsant medication.
M5904 Proparacaine HCl Proparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.
M5899 Procaine Procaine is a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. *The compound is unstable in solutions, freshly prepared is recommended
M5897 Prilocaine Prilocaine is a local anesthetic of the amino amide type. It acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation.
M5876 Phenytoin Sodium Phenytoin Sodium is an inactive voltage-gated sodium channel stabilizer.
M5875 Phenytoin Phenytoin is an inactive voltage-gated sodium channel stabilizer.
M5699 Ibutilide fumarate Ibutilide Fumarate is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells.
M5603 Dyclonine HCl Dyclonine HCl is a hydrochloride salt form of dyclonine which is an oral anaesthetic, reversibly binds to activated sodium channels on the neuronal membrane, thereby decreasing the neuronal membrane's permeability to sodium ions, leading to an increased threshold for excitation.
M5570 Dibucaine Dibucaine is a local anesthetic of the amide type now generally used for surface anesthesia.
M5449 Benzocaine hydrochloride Benzocaine hydrochloride is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
M5069 S0859 S0859 is an N-cyanosulphonamide compound, reversibly inhibit NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM).
M3935 Digoxin Digoxin is widely used in the treatment of various heart conditions, namely atrial fibrillation, atrial flutter and sometimes heart failure that cannot be controlled by other medication.
M3412 Propafenone hydrochloride Propafenone hydrochloride is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.
M3366 Amiloride hydrochloride dihydrate Amiloride hydrochloride dihydrate is a potent epithelial sodium channel blocker.
M3358 Procainamide hydrochloride Procainamide hydrochloride is a sodium channel blocker, and also a DNA methyltransferase inhibitor.
M3354 Carbamazepine Carbamazepine (Carbatrol) is a sodium channel blocker with IC50 of 131 μM in rat brain synaptosomes.
M3345 Primidone Primidone is an anticonvulsant of the pyrimidinedione class.
M3083 Triamterene Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner with IC50 of 4.5 μM.
M2989 Ropivacaine hydrochloride monohydrate Ropivacaine hydrochloride monohydrate is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.
M2961 Procaine hydrochloride Procaine is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with KD of 1.7 μM.
M2904 Ouabain Ouabain is a selective Na+/K+, -ATPase inhibitor, binds to α2 /α3 subunit with Ki of 41 nM/15 nM.
M2802 Lamotrigine Lamotrigine is a novel anticonvulsant compound for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, and also is a sodium channel blocker.
M2632 Dibucaine hydrochloride Dibucaine hydrochloride is a local anesthetics.
M2530 Clopamide Clopamide is an orally active thiazide-like diuretic agent that inhibits the sodium-coupled chloride cotransporter SLC12A3.
M2487 Camostat Mesilate Camostat is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trpsin, prostasin and matriptase.
M2380 Ambroxol hydrochloride AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM.
M2264 Oxcarbazepine Oxcarbazepine is an anticonvulsant and mood-stabilizing compound.
M2210 A-803467 A-803467 is a potent and selective Nav1.8 sodium channel blocker that potently blocks tetrodotoxin-resistant currents (IC50 = 140 nM).
M1968 Riluzole Riluzole (Rilutek) is a sodium channel protein inhibitor and novel psychotropic agent with anticonvulsant, hypnotic, anxiolytic, anti-ischemic and anesthetic properties.
M1427 Lacosamide Lacosamide is a medication developed for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain.

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