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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M10113 | BI01383298 | BI01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5). |
| M9129 | GNE-131 | GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM. |
| M9115 | PF-06869206 | PF-06869206 is an orally bioavailable selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1) with an IC50 of 380 nM. |
| M9103 | Eleclazine hydrochloride | Eleclazine HCl is a novel late Na+ current inhibitor, with IC50 value of 0.7 uM. |
| M9018 | Levobupivacaine | Levobupivacaine is a reversible neuronal sodium channel inhibitor. |
| M8988 | PF-05089771 | PF-05089771 is a selective Nav1.7 channel blocker that interacts with the voltage-sensor domain (VSD) of domain IV. |
| M8947 | PF-01247324 | PF-01247324 is a novel selective and orally bioavailable Nav 1.8 channel blocker with an IC50 of 196 nM for recombinant human Nav1.8 channel. |
| M8911 | GS967 | GS967, also known as GS-458967, is a potent and selective blocker of cardiac late sodium current (late INa) with IC50 values of 0.13 and 0.21 μM for ventricular myocytes and isolated hearts, respectively. |
| M8510 | Cariporide | Cariporide is a selective inhibitor of the Na+/H+ exchanger subtype 1 (NHE-1), also known as the Na+/H+ antiporter. |
| M8092 | PF-05089771 Tosylate | PF-05089771 Tosylate is a selective and potent inhibitor of the human voltage-gated sodium ion channel Nav1. |
| M7572 | Tenapanor | Tenapanor is an inhibitor of the Na+/H+ exchanger NHE3 with IC50 values of 5 and 10 nM against human and Rat NHE3, respectively. |
| M7552 | ETH2120 | Sodium ionophore III (ETH2120) is a Na+ ionophore suitable for the assay of sodium activity in blood, plasma, serum. etc. |
| M7520 | Brivaracetam | Brivaracetam (UCB 34714) is chemically related to levetiracetam (LEV, Keppra). It possesses a binding affinity for the synaptic vesicle protein 2A (SV2A) ten-fold above that of LEV and also shows an ability to inhibit Na+ channels. |
| M6085 | GSK-1014802 | CNV1014802(GSK-1014802) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor. |
| M6068 | Zonisamide | Zonisamide is a voltage-dependent sodium channel and T-type calcium channel blocker, used as an antiepileptic drug. |
| M6054 | Vinpocetine | Vinpocetine is a selective inhibitor of voltage-sensitive sodium channel for the treatment of stroke, vascular dementia and Alzheimer's disease. |
| M6006 | Tetracaine | Tetracaine is a topical local anesthetic for the eyes; works by interfering with entry of sodium ions into nerve cells. |
| M5943 | Rufinamide | Rufinamide is a voltage-gated sodium channel blocker, used an anticonvulsant medication. |
| M5904 | Proparacaine HCl | Proparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM. |
| M5899 | Procaine | Procaine is a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. |
| M5897 | Prilocaine | Prilocaine is a local anesthetic of the amino amide type. It acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. |
| M5876 | Phenytoin Sodium | Phenytoin Sodium is an inactive voltage-gated sodium channel stabilizer. |
| M5875 | Phenytoin | Phenytoin is an inactive voltage-gated sodium channel stabilizer. |
| M5699 | Ibutilide fumarate | Ibutilide Fumarate is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells. |
| M5603 | Dyclonine HCl | Dyclonine HCl is a hydrochloride salt form of dyclonine which is an oral anaesthetic, reversibly binds to activated sodium channels on the neuronal membrane, thereby decreasing the neuronal membrane's permeability to sodium ions, leading to an increased threshold for excitation. |
| M5570 | Dibucaine | Dibucaine is a local anesthetic of the amide type now generally used for surface anesthesia. |
| M5449 | Benzocaine hydrochloride | Benzocaine hydrochloride is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. |
| M5069 | S0859 | S0859 is an N-cyanosulphonamide compound, reversibly inhibit NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM). |
| M3935 | Digoxin | Digoxin is widely used in the treatment of various heart conditions, namely atrial fibrillation, atrial flutter and sometimes heart failure that cannot be controlled by other medication. |
| M3412 | Propafenone hydrochloride | Propafenone hydrochloride is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias. |
| M3366 | Amiloride hydrochloride dihydrate | Amiloride hydrochloride dihydrate is a potent epithelial sodium channel blocker. |
| M3358 | Procainamide hydrochloride | Procainamide hydrochloride is a sodium channel blocker, and also a DNA methyltransferase inhibitor. |
| M3354 | Carbamazepine | Carbamazepine (Carbatrol) is a sodium channel blocker with IC50 of 131 μM in rat brain synaptosomes. |
| M3345 | Primidone | Primidone is an anticonvulsant of the pyrimidinedione class. |
| M3083 | Triamterene | Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner with IC50 of 4.5 μM. |
| M2989 | Ropivacaine hydrochloride | Ropivacaine hydrochloride is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly. |
| M2961 | Procaine hydrochloride | Procaine is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with KD of 1.7 μM. |
| M2904 | Ouabain | Ouabain is a selective Na+/K+, -ATPase inhibitor, binds to α2 /α3 subunit with Ki of 41 nM/15 nM. |
| M2802 | Lamotrigine | Lamotrigine is a novel anticonvulsant compound for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, and also is a sodium channel blocker. |
| M2632 | Dibucaine hydrochloride | Dibucaine hydrochloride is a local anesthetics. |
| M2487 | Camostat Mesilate | Camostat is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trpsin, prostasin and matriptase. |
| M2380 | Ambroxol hydrochloride | AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. |
| M2264 | Oxcarbazepine | Oxcarbazepine is an anticonvulsant and mood-stabilizing compound. |
| M2210 | A-803467 | A-803467 is a potent and selective Nav1.8 sodium channel blocker that potently blocks tetrodotoxin-resistant currents (IC50 = 140 nM). |
| M1968 | Riluzole | Riluzole (Rilutek) is a sodium channel protein inhibitor and novel psychotropic agent with anticonvulsant, hypnotic, anxiolytic, anti-ischemic and anesthetic properties. |
| M1427 | Lacosamide | Lacosamide is a medication developed for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. |
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