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Abmole Inhibitor Catalog 2017

Sodium Channel Sodium Channel

Inhibitors

Cat.No.  Name Information
M6085 GSK-1014802 CNV1014802(GSK-1014802) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor.
M6068 Zonisamide Zonisamide is a voltage-dependent sodium channel and T-type calcium channel blocker, used as an antiepileptic drug.
M6054 Vinpocetine Vinpocetine is a selective inhibitor of voltage-sensitive sodium channel for the treatment of stroke, vascular dementia and Alzheimer's disease.
M6006 Tetracaine Tetracaine is a topical local anesthetic for the eyes; works by interfering with entry of sodium ions into nerve cells.
M5943 Rufinamide Rufinamide是一种电压门控式的sodium channel阻断剂,用作抗惊厥的药物。
M5904 Proparacaine HCl Proparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.
M5899 Procaine Procaine is a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses.
M5897 Prilocaine Prilocaine is a local anesthetic of the amino amide type. It acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation.
M5876 Phenytoin Sodium Phenytoin Sodium is an inactive voltage-gated sodium channel stabilizer.
M5875 Phenytoin Phenytoin is an inactive voltage-gated sodium channel stabilizer.
M5699 Ibutilide fumarate Ibutilide Fumarate is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells.
M5603 Dyclonine HCl Dyclonine HCl is a hydrochloride salt form of dyclonine which is an oral anaesthetic, reversibly binds to activated sodium channels on the neuronal membrane, thereby decreasing the neuronal membrane's permeability to sodium ions, leading to an increased threshold for excitation.
M5570 Dibucaine Dibucaine is a local anesthetic of the amide type now generally used for surface anesthesia.
M5449 Benzocaine Benzocaine hydrochloride is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
M3412 Propafenone hydrochloride Propafenone hydrochloride is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.
M3366 Amiloride hydrochloride dihydrate Amiloride hydrochloride dihydrate is a potent epithelial sodium channel blocker.
M3358 Procainamide hydrochloride Procainamide hydrochloride is a sodium channel blocker, and also a DNA methyltransferase inhibitor.
M3354 Carbamazepine Carbamazepine (Carbatrol) is a sodium channel blocker with IC50 of 131 μM in rat brain synaptosomes.
M3083 Triamterene Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner with IC50 of 4.5 μM.
M2961 Procaine hydrochloride Procaine is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with KD of 1.7 μM.
M2904 Ouabain Ouabain is a selective Na+/K+, -ATPase inhibitor, binds to α2 /α3 subunit with Ki of 41 nM/15 nM.
M2802 Lamotrigine Lamotrigine is a novel anticonvulsant compound for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, and also is a sodium channel blocker.
M2632 Dibucaine hydrochloride Dibucaine hydrochloride is a local anesthetics.
M2380 Ambroxol hydrochloride AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM.
M2264 Oxcarbazepine Oxcarbazepine is an anticonvulsant and mood-stabilizing compound.
M2210 A-803467 A-803467 is a potent and selective Nav1.8 sodium channel blocker that potently blocks tetrodotoxin-resistant currents (IC50 = 140 nM).
M1968 Riluzole Riluzole (Rilutek) is a sodium channel protein inhibitor and novel psychotropic agent with anticonvulsant, hypnotic, anxiolytic, anti-ischemic and anesthetic properties.


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