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Abmole Inhibitor Catalog 2017

Sodium Channel Sodium Channel

Inhibitors

Cat.No.  Name Information
M5449 Benzocaine Benzocaine hydrochloride is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
M3412 Propafenone hydrochloride Propafenone hydrochloride is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.
M3366 Amiloride hydrochloride dihydrate Amiloride hydrochloride dihydrate is a potent epithelial sodium channel blocker.
M3358 Procainamide hydrochloride Procainamide hydrochloride is a sodium channel blocker, and also a DNA methyltransferase inhibitor.
M3354 Carbamazepine Carbamazepine (Carbatrol) is a sodium channel blocker with IC50 of 131 μM in rat brain synaptosomes.
M3083 Triamterene Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner with IC50 of 4.5 μM.
M2961 Procaine hydrochloride Procaine is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with KD of 1.7 μM.
M2904 Ouabain Ouabain is a selective Na+/K+, -ATPase inhibitor, binds to α2 /α3 subunit with Ki of 41 nM/15 nM.
M2802 Lamotrigine Lamotrigine is a novel anticonvulsant compound for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, and also is a sodium channel blocker.
M2632 Dibucaine hydrochloride Dibucaine hydrochloride is a local anesthetics.
M2380 Ambroxol hydrochloride AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM.
M2264 Oxcarbazepine Oxcarbazepine is an anticonvulsant and mood-stabilizing compound.
M2210 A-803467 A-803467 is a potent and selective Nav1.8 sodium channel blocker that potently blocks tetrodotoxin-resistant currents (IC50 = 140 nM).
M1968 Riluzole Riluzole (Rilutek) is a sodium channel protein inhibitor and novel psychotropic agent with anticonvulsant, hypnotic, anxiolytic, anti-ischemic and anesthetic properties.

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