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Riluzole hydrochloride

Cat. No. M14274
Riluzole hydrochloride Structure
Synonym:

PK 26124 hydrochloride

Size Price Availability
50mg USD 85  USD85 4-7 Days
100mg USD 140  USD140 4-7 Days
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Quality Control & Documentation
Biological Activity

Riluzole hydrochloride is an anticonvulsant drug and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM.

Chemical Information
Molecular Weight 270.66
CAS Number 850608-87-6
Solubility (25°C) DMSO 90 mg/mL
Water 4.17 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Pradip Kumar Mondal, et al. Crystal structure analysis of the biologically active drug mol-ecule riluzole and riluzolium chloride

[2] Satoru Morimoto, et al. Ropinirole hydrochloride remedy for amyotrophic lateral sclerosis - Protocol for a randomized, double-blind, placebo-controlled, single-center, and open-label continuation phase I/IIa clinical trial (ROPALS trial)

[3] Selin stn Bezgin, et al. The Effects of Riluzole on Cisplatin-induced Ototoxicity

[4] Julia M Richter, et al. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5

[5] Latha Ramakrishnan, et al. Riluzole attenuates the effects of chemoconvulsants acting on glutamatergic and GABAergic neurotransmission in the planarian Dugesia tigrina

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  Catalog
Abmole Inhibitor Catalog




Keywords: Riluzole hydrochloride, PK 26124 hydrochloride supplier, Sodium Channel, inhibitors, activators


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