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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M9307 | TC-S 7005 | TC-S 7005 is a potent and selective polo-like kinase 2 (PLK2) inhibitor (IC50 = 4 nM). |
| M9250 | HMN-176 | HMN-176 inhibits mitosis, interfering with polo-like kinase-1 (plk1), without significant effect on tubulin polymerization. |
| M8519 | Mps1-IN-2 | Mps1-IN-2 is a potent and selective inhibitor of Mps1 kinase. |
| M7559 | ON1231320 | ON1231320, also known as GBO-006, is a Polo-like kinase 2 (PLK2) inhibitor. In vitro testing revealed that ON1231320 is a selective inhibitor of PLK2 with no inhibitory activity against PLK1, PLK3 and PLK4. |
| M7271 | SBE13 hydrochloride | SBE13 hydrochloride is a potent and selective PLK1 inhibitor. |
| M3293 | HMN-214 | HMN-214 is a procompound of HMN-176, which alters the cellular spatial orientation of Plk1. |
| M3198 | TAK-960 | TAK-960 is a novel, potent and selective Plk1 inhibitor with IC50 of 8 nM. |
| M2983 | Ro3280 | RO3280 is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3 nM. |
| M2860 | MLN0905 | MLN0905 is a potent inhibitor of PLK1 with IC50 of 2 nM. |
| M2741 | GW843682X | GW 843682X is a PLK inhibitor for PLK1 and PLK3 with IC50 of 2.2 nM and 9.1 nM, respectively. |
| M2211 | Rigosertib | Rigosertib is a dual non-ATP inhibitor of polo-like kinase 1 (Plk1) and phosphoinositide 3-kinase pathways (PI3K). |
| M1719 | GSK461364 | GSK461364 is a potent and selective small molecule inhibitor of Polo-like kinase 1 (PLK1) with a Ki of 2.2 nM. |
| M1678 | BI 6727 | BI 6727 (Volasertib) is a small highly potent Polo-like kinase inhibitor (Plk1) with an IC50 of 0 .87 nM. |
| M1672 | BI 2536 | BI 2536 is a novel, highly selective, potent inhibitor of Polo-like kinase 1 (Plk1) with an IC50 of 0.83 nM. |
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