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MLN0905 is a potent inhibitor of PLK1 with IC50 of 2 nM.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
| Molecular Weight | 486.56 |
| Formula | C24H25F3N6S |
| CAS Number | 1228960-69-7 |
| Purity | >98% |
| Solubility | DMSO 80 mg/mL |
| Storage | at -20°C |
| Related PLK Products |
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| HMN-176
HMN-176 inhibits mitosis, interfering with polo-like kinase-1 (plk1), without significant effect on tubulin polymerization. |
| ON1231320
ON1231320, also known as GBO-006, is a Polo-like kinase 2 (PLK2) inhibitor. In vitro testing revealed that ON1231320 is a selective inhibitor of PLK2 with no inhibitory activity against PLK1, PLK3 and PLK4. |
| SBE13 hydrochloride
SBE13 hydrochloride is a potent and selective PLK1 inhibitor. |
| HMN-214
HMN-214 is a procompound of HMN-176, which alters the cellular spatial orientation of Plk1. |
| TAK-960
TAK-960 is a novel, potent and selective Plk1 inhibitor with IC50 of 8 nM. |
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