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GW843682X

Cat. No. M2741
GW843682X Structure
Size Price Availability Quantity
5mg USD 90 In stock
10mg USD 140 In stock
50mg USD 540 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

GW 843682X is a PLK inhibitor for PLK1 and PLK3 with IC50 of 2.2 nM and 9.1 nM, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 477.46
Formula C22H18F3N3O4S
CAS Number 660868-91-7
Purity >99%
Solubility DMSO
Storage at -20°C
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Ro3280

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MLN0905

MLN0905 is a potent inhibitor of PLK1 with IC50 of 2 nM.

Rigosertib

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: GW843682X supplier, PLK, inhibitors

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