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Ro3280

Cat. No. M2983
Ro3280 Structure
Synonym:

Ro5203280

Size Price Availability Quantity
5mg USD 160 In stock
10mg USD 260 In stock
50mg USD 940 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

RO3280 is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3 nM.

Customer Product Validations & Biological Datas
Source Oncol Rep (2017). Figure 2. Ro3280
Method Western blotting
Cell Lines NB4 cells
Concentrations 200 and 500 nM
Incubation Time 4 h
Results Western blotting showed more LC3-II in NB4 cells treated with RO3280 and BI2536. More LC3-II was observed in the 100-500 nM RO3280 group and in the 200-500 nM BI2536 group
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 543.61
Formula C27H35F2N7O3
CAS Number 1062243-51-9
Purity >99%
Solubility DMSO 90 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Ro3280, Ro5203280 supplier, PLK, inhibitors

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