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  Catalog
Abmole Inhibitor Catalog 2017

PARP Poly-ADP-ribose polymerase

Inhibitors

Cat.No.  Name Information
M5547 Daidzein Daidzein is an inactive analogue of genistein, a tyrosine kinase inhibitor and an estrogen receptor activator.
M5270 NMS-P118 NMS-P118 is a potent, orally available, and highly selective PARP-1 inhibitor endowed with excellent ADME and pharmacokinetic profiles, showing 150-fold selectivity for PARP-1 over PARP-2 (Kd 0.009 μM vs 1.39 μM, respectively).
M5267 E7449 E7449 is an orally bioavailable, brain penetrable, small molecule dual inhibitor of PARP1/2 that also inhibits PARP5a/5b, otherwise known as tankyrase1 and 2 (TNKS1/2), important regulators of canonical Wnt/β-catenin signaling. It has IC50 values of 1.0 and 1.2 nM for PARP1 and 2, respectively.
M4855 BMN673 isomer
M4854 BMN-673 8R,9S BMN-673 (8R,9S) is the (8R,9S) enantiomer of BMN-673.BMN673 is a potent inhibitor of poly (ADP-ribose) polymerases (PARP)-1 and -2.
M3932 NVP-TNKS656 NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM; > 300 fold selectivity against PARP1 and PARP2.
M3703 LT-626 LT-626 is a PARP inhibitor with an IC50 value of IC50 from 0.1-5.8 µM.
M3615 UPF 1069 UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM which is ~27-fold selective against PARP1.
M3410 A-966492 A-966492 is a novel and potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, respectively.
M2951 PJ34 PJ-34 is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.
M2831 ME0328 ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.
M2587 JW55 JW 55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). JW55 decreased auto-PARsylation of TNKS1/2 in vitro with IC50 values of 1.9 uM and 830 nM respectively.
M2419 AZD2461 AZD2461 is a novel PARP inhibitor with low affinity for Pgp than Olaparib.
M2215 MK-4827 MK-4827 is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor with IC50 of 3.8 and 2.1 nM, respectively.
M2056 PJ34 hydrochloride PJ34 is a novel potent inhibitor of poly(ADP-ribose) polymerase (PARP) with EC50 of 20 nM.
M2010 BSI-401 BSI-401 is a novel poly (ADP ribose) polymerase-1 inhibitor.
M1972 Iniparib Iniparib is an irreversible, noncompetitive inhibitor of PARP1 that disrupts binding between PARP1 and DNA by interacting with the DNA binding domain.
M1858 LT-674 LT-674 inhibits PARP-1 with an IC50 of 144 nM.
M1857 LT-628 LT-628 is the racemate of BMN 673 and LT-674.
M1785 INO-1001 INO-1001 is a novel poly(ADP-ribose) polymerase (PARP) inhibitor with an IC50 of 3 nM.
M1732 BMN673 BMN673 is a potent inhibitor of poly (ADP-ribose) polymerases (PARP)-1 and -2.
M1664 AZD2281 AZD 2281 (Olaparib, KU-0059436) is a potent PARP (poly ADP-ribose polymerase) inhibitorwith IC50 of 5 and 1 nM for PARP-1and PARP-2 respectively.
M1645 AG14361 AG14361 is a novel poly (ADP-ribose) polymerase-1 inhibitor with a GI50 of 10.9 µM.
M1644 AG-014699 AG-014699 (PF-01367338, Rucaparib) is a PARP inhibitor with a Ki of 1.4 nM.
M1639 ABT-888 ABT-888 (Veliparib) is a potent inhibitor of PARP-1 and PARP-2 with Ki values of 5.2nM and 2.9nM respectively.


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