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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M1732 | BMN673 (Talazoparib) | Talazoparib (BMN-673) 是一种高效的，具有口服活性的 PARP 1/2 抑制剂。Talazoparib 抑制 PARP1 和 PARP2 酶活性的 Ki 值分别为 1.2 nM 和 0.87 nM。Talazoparib 具有抗肿瘤活性。 |
| M3932 | NVP-TNKS656 | NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM; > 300 fold selectivity against PARP1 and PARP2. |
| M4931 | Rucaparib | Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM for PARP1, also showing binding affinity to eight other PARP domains. |
| M1664 | AZD2281 (Olaparib) | AZD 2281 (Olaparib, KU-0059436) is a potent PARP (poly ADP-ribose polymerase) inhibitorwith IC50 of 5 and 1 nM for PARP-1and PARP-2 respectively. |
| M2215 | Niraparib (MK-4827) | Niraparib (MK-4827) is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor with IC50 of 3.8 and 2.1 nM, respectively. |
| M21447 | Amelparib | Amelparib is a potent, water soluble PARP-1 inhibitor with oral activity. |
| M13715 | Veliparib dihydrochloride | Veliparib (dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Kis of 5.2 nM and 2.9 nM in cell-free assays, respectively. |
| M13714 | Talazoparib tosylate | Talazoparib tosylate (BMN 673ts) is a novel, potent and orally available PARP1/2 inhibitor with an IC50 of 0.57 nM for PARP1. |
| M13713 | RK-287107 | RK-287107 is a potent and specific tankyrase inhibitor with IC50s of 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively. RK-287107 blocks colorectal cancer cell growth. |
| M13712 | PARP1-IN-5 dihydrochloride | PARP1-IN-5 dihydrochloride is a low toxicity, orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 dihydrochloride can be used for the research of cancer. |
| M13711 | Niraparib hydrochloride | Niraparib hydrochloride (MK-4827 hydrochloride) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. |
| M13710 | iRucaparib-AP6 | iRucaparib-AP6 is a highly efficient and specific PARP1 degrader based on Rucaparib by using the PROTAC approach. iRucaparib-AP6, a non-trapping PARP1 degrader, blocks both the catalytic activity and scaffolding effects of PARP1. |
| M13709 | INO-1001 | INO-1001 is a potent and selective poly (ADP-ribose) polymerase (PARP) inhibitor. |
| M13431 | KSQ-4279 | KSQ-4279 (USP1-IN-1) is an inhibitor of USP1 and PARP. |
| M13392 | GeA-69 | GeA-69 is a cell-penetrating selective allosteric inhibitor targeting Macrodomain 2 (MD2) with a Kd of 2.1 µM. |
| M13391 | RBN012759 | RBN012759 is a potent, selective and orally active PARP14 inhibitor with IC50 values of <3 nM and 5 nM against the human and mouse catalytic domains, respectively. AIDS in the anti-tumor immune response. |
| M11443 | KSQ-4279 | Usp1-in-1 (Formula I), an allosteric INHIBITOR of USP1, has been used IN cancer studies alone or IN combination with PARP inhibition. |
| M10445 | Fluzoparib (SHR3162) | Fluzoparib (SHR3162) is an effective oral active PARP1 inhibitor (IC50=1.46±0.72 nM) with superior antitumor activity. Fluzoparib selectively inhibited the proliferation of homologous recombination repair (HR) deficient cells and sensitized HR deficient cells to cytotoxic drugs. Fluzoparib has good pharmacokinetic properties in vivo and can be used in cancer research. |
| M10298 | AZD5305 | AZD5305 is a potent and oral active, second-generation PARP (highly selective PARP1) inhibitor. |
| M9864 | BRCA1-IN-2 | BRCA1-IN-2 is a cell-permeable protein-protein interaction (PPI) inhibitor for BRCA1, with IC50 of 0.31 μM and Kd of 0.3 μM. |
| M9602 | RBN-2397 | RBN-2397 is a potent, orally active NAD+ competitive PARP7 inhibitor with an IC50 value of less than 3 nM. Rnb-2397 can directly inhibit cell proliferation and restore type I interferon signaling by inhibiting PARP7 in tumor cells to stimulate innate or adaptive antitumor immune responses |
| M9525 | Pamiparib | Pamiparib (BGB-290) is an orally active, potent, highly selective inhibitor of PARP1 and PARP2 with IC50 values of 0.9 nM and 0.5 nM, respectively. |
| M9253 | BGP-15 2HCl | BGP-15 is a novel poly(ADP-ribose) polymerase inhibitor with an IC50 and a Ki of 120 μM and 57 μM, respectively. |
| M9139 | Benzamide | Benzamide is an inhibitor of poly(ADP-ribose) polymerase with an IC50 of 3.3 μM. |
| M9138 | Picolinamide | Picolinamide is a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells. |
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