Catalog

PARP Poly-ADP-ribose polymerase

Inhibitors

Cat.No.	Name	Information
M9864	BRCA1-IN-2	BRCA1-IN-2 is a cell-permeable protein-protein interaction (PPI) inhibitor for BRCA1, with IC50 of 0.31 μM and Kd of 0.3 μM.
M9602	RBN-2397	RBN-2397 is a potent and orally active NAD+ competitive inhibitor of PARP7 (IC50<3 nM).
M9525	Pamiparib	Pamiparib (BGB-290) is an orally active, potent, highly selective inhibitor of PARP1 and PARP2 with IC50 values of 0.9 nM and 0.5 nM, respectively.
M9253	BGP-15 2HCl	BGP-15 is a novel poly(ADP-ribose) polymerase inhibitor with an IC50 and a Ki of 120 μM and 57 μM, respectively.
M9139	Benzamide	Benzamide is an inhibitor of poly(ADP-ribose) polymerase with an IC50 of 3.3 μM.
M9138	Picolinamide	Picolinamide is a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.
M8926	Niraparib (MK-4827) tosylate	Niraparib (MK-4827) tosylate is an excellent PARP1 and PARP2 inhibitor with IC50 of 3.8 and 2.1 nM, respectively.
M5547	Daidzein	Daidzein is an inactive analogue of genistein, a tyrosine kinase inhibitor and an estrogen receptor activator.
M5270	NMS-P118	NMS-P118 is a potent, orally available, and highly selective PARP-1 inhibitor endowed with excellent ADME and pharmacokinetic profiles, showing 150-fold selectivity for PARP-1 over PARP-2 (Kd 0.009 μM vs 1.39 μM, respectively).
M5267	E7449	E7449 is an orally bioavailable, brain penetrable, small molecule dual inhibitor of PARP1/2 that also inhibits PARP5a/5b, otherwise known as tankyrase1 and 2 (TNKS1/2), important regulators of canonical Wnt/β-catenin signaling. It has IC50 values of 1.0 and 1.2 nM for PARP1 and 2, respectively.
M4931	Rucaparib	Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM for PARP1, also showing binding affinity to eight other PARP domains.
M4855	BMN673 isomer
M4854	BMN-673 8R,9S	BMN-673 (8R,9S) is the (8R,9S) enantiomer of BMN-673.BMN673 is a potent inhibitor of poly (ADP-ribose) polymerases (PARP)-1 and -2.
M3932	NVP-TNKS656	NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM; > 300 fold selectivity against PARP1 and PARP2.
M3615	UPF 1069	UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM which is ~27-fold selective against PARP1.
M3410	A-966492	A-966492 is a novel and potent inhibitor of PARP1 and PARP2 with K_i of 1 nM and 1.5 nM, respectively.
M2951	PJ34	PJ-34 is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.
M2831	ME0328	ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.
M2587	JW55	JW 55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). JW55 decreased auto-PARsylation of TNKS1/2 in vitro with IC50 values of 1.9 uM and 830 nM respectively.
M2419	AZD2461	AZD2461 is a novel PARP inhibitor with low affinity for Pgp than Olaparib.
M2215	MK-4827	MK-4827 is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor with IC50 of 3.8 and 2.1 nM, respectively.
M2056	PJ34 hydrochloride	PJ34 is a novel potent inhibitor of poly(ADP-ribose) polymerase (PARP) with EC50 of 20 nM.
M2010	BSI-401	BSI-401 is a novel poly (ADP ribose) polymerase-1 inhibitor.
M1972	Iniparib	Iniparib is an irreversible, noncompetitive inhibitor of PARP1 that disrupts binding between PARP1 and DNA by interacting with the DNA binding domain.
M1858	LT-674	LT-674 inhibits PARP-1 with an IC50 of 144 nM.
M1857	LT-628	LT-628 is the racemate of BMN 673 and LT-674.
M1785	INO-1001	INO-1001 is a novel poly(ADP-ribose) polymerase (PARP) inhibitor with an IC50 of 3 nM.
M1732	BMN673	BMN673 is a potent inhibitor of poly (ADP-ribose) polymerases (PARP)-1 and -2.
M1664	AZD2281 (Olaparib)	AZD 2281 (Olaparib, KU-0059436) is a potent PARP (poly ADP-ribose polymerase) inhibitorwith IC50 of 5 and 1 nM for PARP-1and PARP-2 respectively.
M1645	AG14361	AG14361 is a novel poly (ADP-ribose) polymerase-1 inhibitor with a GI50 of 10.9 µM.
M1644	AG-014699 phosphate	AG-014699 (PF-01367338, Rucaparib) is a PARP inhibitor with a Ki of 1.4 nM.
M1639	ABT-888	ABT-888 (Veliparib) is a potent inhibitor of PARP-1 and PARP-2 with Ki values of 5.2nM and 2.9nM respectively.

Signaling Pathways

Product Type

PARP Poly-ADP-ribose polymerase

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