Inhibitors
Cat.No. | Name | Information |
---|---|---|
M9864 | BRCA1-IN-2 | BRCA1-IN-2 is a cell-permeable protein-protein interaction (PPI) inhibitor for BRCA1, with IC50 of 0.31 μM and Kd of 0.3 μM. |
M9602 | RBN-2397 | RBN-2397 is a potent and orally active NAD+ competitive inhibitor of PARP7 (IC50<3 nM). |
M9525 | Pamiparib | Pamiparib (BGB-290) is an orally active, potent, highly selective inhibitor of PARP1 and PARP2 with IC50 values of 0.9 nM and 0.5 nM, respectively. |
M9253 | BGP-15 2HCl | BGP-15 is a novel poly(ADP-ribose) polymerase inhibitor with an IC50 and a Ki of 120 μM and 57 μM, respectively. |
M9139 | Benzamide | Benzamide is an inhibitor of poly(ADP-ribose) polymerase with an IC50 of 3.3 μM. |
M9138 | Picolinamide | Picolinamide is a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells. |
M8926 | Niraparib (MK-4827) tosylate | Niraparib (MK-4827) tosylate is an excellent PARP1 and PARP2 inhibitor with IC50 of 3.8 and 2.1 nM, respectively. |
M5547 | Daidzein | Daidzein is an inactive analogue of genistein, a tyrosine kinase inhibitor and an estrogen receptor activator. |
M5270 | NMS-P118 | NMS-P118 is a potent, orally available, and highly selective PARP-1 inhibitor endowed with excellent ADME and pharmacokinetic profiles, showing 150-fold selectivity for PARP-1 over PARP-2 (Kd 0.009 μM vs 1.39 μM, respectively). |
M5267 | E7449 | E7449 is an orally bioavailable, brain penetrable, small molecule dual inhibitor of PARP1/2 that also inhibits PARP5a/5b, otherwise known as tankyrase1 and 2 (TNKS1/2), important regulators of canonical Wnt/β-catenin signaling. It has IC50 values of 1.0 and 1.2 nM for PARP1 and 2, respectively. |
M4931 | Rucaparib | Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM for PARP1, also showing binding affinity to eight other PARP domains. |
M4855 | BMN673 isomer | |
M4854 | BMN-673 8R,9S | BMN-673 (8R,9S) is the (8R,9S) enantiomer of BMN-673.BMN673 is a potent inhibitor of poly (ADP-ribose) polymerases (PARP)-1 and -2. |
M3932 | NVP-TNKS656 | NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM; > 300 fold selectivity against PARP1 and PARP2. |
M3615 | UPF 1069 | UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM which is ~27-fold selective against PARP1. |
M3410 | A-966492 | A-966492 is a novel and potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, respectively. |
M2951 | PJ34 | PJ-34 is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2. |
M2831 | ME0328 | ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1. |
M2587 | JW55 | JW 55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). JW55 decreased auto-PARsylation of TNKS1/2 in vitro with IC50 values of 1.9 uM and 830 nM respectively. |
M2419 | AZD2461 | AZD2461 is a novel PARP inhibitor with low affinity for Pgp than Olaparib. |
M2215 | MK-4827 | MK-4827 is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor with IC50 of 3.8 and 2.1 nM, respectively. |
M2056 | PJ34 hydrochloride | PJ34 is a novel potent inhibitor of poly(ADP-ribose) polymerase (PARP) with EC50 of 20 nM. |
M2010 | BSI-401 | BSI-401 is a novel poly (ADP ribose) polymerase-1 inhibitor. |
M1972 | Iniparib | Iniparib is an irreversible, noncompetitive inhibitor of PARP1 that disrupts binding between PARP1 and DNA by interacting with the DNA binding domain. |
M1858 | LT-674 | LT-674 inhibits PARP-1 with an IC50 of 144 nM. |
M1857 | LT-628 | LT-628 is the racemate of BMN 673 and LT-674. |
M1785 | INO-1001 | INO-1001 is a novel poly(ADP-ribose) polymerase (PARP) inhibitor with an IC50 of 3 nM. |
M1732 | BMN673 | BMN673 is a potent inhibitor of poly (ADP-ribose) polymerases (PARP)-1 and -2. |
M1664 | AZD2281 (Olaparib) | AZD 2281 (Olaparib, KU-0059436) is a potent PARP (poly ADP-ribose polymerase) inhibitorwith IC50 of 5 and 1 nM for PARP-1and PARP-2 respectively. |
M1645 | AG14361 | AG14361 is a novel poly (ADP-ribose) polymerase-1 inhibitor with a GI50 of 10.9 µM. |
M1644 | AG-014699 phosphate | AG-014699 (PF-01367338, Rucaparib) is a PARP inhibitor with a Ki of 1.4 nM. |
M1639 | ABT-888 | ABT-888 (Veliparib) is a potent inhibitor of PARP-1 and PARP-2 with Ki values of 5.2nM and 2.9nM respectively. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.