| Cat.No. | Name | Information |
|---|---|---|
| M1732 | Talazoparib (BMN-673) | Talazoparib (BMN-673) is a highly potent, orally active PARP1/2 inhibitor.Talazoparib inhibits PARP1 and PARP2 enzyme activity with Kis of 1.2 nM and 0.87 nM, respectively. Talazoparib has antitumor activity. |
| M3932 | NVP-TNKS656 | NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM; > 300 fold selectivity against PARP1 and PARP2. |
| M4931 | Rucaparib | Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM for PARP1, also showing binding affinity to eight other PARP domains. |
| M1664 | AZD2281 (Olaparib) | AZD 2281 (Olaparib, KU-0059436) is a potent PARP (poly ADP-ribose polymerase) inhibitorwith IC50 of 5 and 1 nM for PARP-1and PARP-2 respectively. Olaparib is an autophagy and mitophagy activator. |
| M2215 | Niraparib (MK-4827) | MK-4827 (Niraparib) is a selective PARP1/2 inhibitor with an IC50 value of 3.8 nM/2.1 nM that increases the formation of PARP-DNA complexes through inhibition of PARPase activity, leading to DNA damage, apoptosis, PARP-1-dependent cell death (parthanatos) and cell death. Strong effector activity when acting on cancer cells harboring mutant BRCA-1 and BRCA-2. It is more than 330-fold more selective than PARP3, V-PARP and Tank1. |
| M1785 | INO-1001 | INO-1001 is a novel poly(ADP-ribose) polymerase (PARP) inhibitor with an IC50 of 3 nM. |
| M13713 | RK-287107 | RK-287107 is a potent and specific tankyrase inhibitor with IC50s of 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively. RK-287107 blocks colorectal cancer cell growth. |
| M9525 | Pamiparib | Pamiparib (BGB-290) is an orally active, potent, highly selective inhibitor of PARP1 and PARP2 with IC50 values of 0.9 nM and 0.5 nM, respectively. |
| M9253 | BGP-15 2HCl | BGP-15 is a novel poly(ADP-ribose) polymerase inhibitor with an IC50 and a Ki of 120 μM and 57 μM, respectively. |
| M9139 | Benzamide | Benzamide is an inhibitor of poly(ADP-ribose) polymerase with an IC50 of 3.3 μM. |
| M9138 | Picolinamide | Picolinamide is a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells. |
| M8926 | Niraparib (MK-4827) tosylate | Niraparib (MK-4827) tosylate is an excellent PARP1 and PARP2 inhibitor with IC50 of 3.8 and 2.1 nM, respectively. |
| M8660 | K-756 | K-756 is an orally available, potent and selective tankyrase inhibitor, which binds to the induced-pocket of tankyrase. |
| M6549 | BYK 204165 | BYK 204165 is a selective PARP-1 inhibitor. |
| M6477 | AZ 6102 | AZ 6102 is a potent TNKS1/2 inhibitor. |
| M5851 | Rucaparib Camsylate | Rucaparib camsylate is a PARP1, 2 and 3 inhibitor. |
| M5547 | Daidzein | Daidzein is an inactive analogue of genistein, a tyrosine kinase inhibitor and an estrogen receptor activator. |
| M5270 | NMS-P118 | NMS-P118 is a potent, orally available, and highly selective PARP-1 inhibitor endowed with excellent ADME and pharmacokinetic profiles, showing 150-fold selectivity for PARP-1 over PARP-2 (Kd 0.009 μM vs 1.39 μM, respectively). |
| M5267 | E7449 | E7449 is an orally bioavailable, brain penetrable, small molecule dual inhibitor of PARP1/2 that also inhibits PARP5a/5b, otherwise known as tankyrase1 and 2 (TNKS1/2), important regulators of canonical Wnt/β-catenin signaling. It has IC50 values of 1.0 and 1.2 nM for PARP1 and 2, respectively. |
| M4855 | BMN673 isomer | (8R,9S)-Talazoparib is the 8R,9S enantiomer of Talazoparib. (8R,9S)-Talazoparib is a PARP1 inhibitor with an IC50 value of 144 nM. |
| M4854 | BMN-673 8R,9S | BMN-673 (8R,9S) is the (8R,9S) enantiomer of BMN-673.BMN673 is a potent inhibitor of poly (ADP-ribose) polymerases (PARP)-1 and -2. |
| M3615 | UPF 1069 | UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM which is ~27-fold selective against PARP1. |
| M3410 | A-966492 | A-966492 is a novel and potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, respectively. |
| M2951 | PJ34 | PJ34 is a PARP inhibitor that also inhibits PARP-1-dependent cell death (parthanatos) with an EC50 of 20 nM, acting with equal effect on PARP1/2. |
| M2831 | ME0328 | ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1. |
| M2587 | JW55 | JW 55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). JW55 decreased auto-PARsylation of TNKS1/2 in vitro with IC50 values of 1.9 uM and 830 nM respectively. |
| M2419 | AZD2461 | AZD2461 is a novel PARP inhibitor with low affinity for Pgp than Olaparib. |
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