Catalog

p53 Tumor protein p53

Inhibitors

Cat.No.	Name	Information
M7994	PRIMA-1	PRIMA-1 is a selective re-activator of mutant p53 activity in tumor cells, and an inducer of apoptosis and inhibitor of growth of human tumors with mutant p53.
M6301	SAR405838	MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.
M5192	NSC59984	NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation.
M3159	Tenovin-3	Tenovin-3 increases p53 levels. Tenovin-3 increase K40 Ac-tubulin levels.
M2943	Pifithrin-μ	Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.
M2891	NSC 319726	NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells.
M2578	RITA	RITA (NSC 652287) is a MDM2 inhibitor and DNA damage agent for A498 (wild type) and TK-10 (mutation) cell lines with a GI50 of 17 nM and 32 nM, respectively.
M2570	Tenovin-6	Tenovin-6 is a small molecule activator of p53 transcriptional activity.
M2068	JNJ-26854165	JNJ-26854165 (Serdemetan) is a novel activator of p53 capable of inducing apoptosis in cancer cell lines.
M2036	Pifithrin-α	Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis.
M2027	Tenovin-1	Tenovin-1 is a small molecule activator of p53 transcriptional activity.