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Abmole Inhibitor Catalog 2017

p53 Tumor protein p53

Inhibitors

Cat.No.  Name Information
M5192 NSC59984 NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation.
M3159 Tenovin-3 Tenovin-3 increases p53 levels. Tenovin-3 increase K40 Ac-tubulin levels.
M2943 Pifithrin-μ Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.
M2891 NSC 319726 NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells.
M2578 RITA RITA (NSC 652287) is a MDM2 inhibitor and DNA damage agent for A498 (wild type) and TK-10 (mutation) cell lines with a GI50 of 17 nM and 32 nM, respectively.
M2570 Tenovin-6 Tenovin-6 is a small molecule activator of p53 transcriptional activity.
M2068 JNJ-26854165 JNJ-26854165 (Serdemetan) is a novel activator of p53 capable of inducing apoptosis in cancer cell lines.
M2036 Pifithrin-α Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis.
M2027 Tenovin-1 Tenovin-1 is a small molecule activator of p53 transcriptional activity.


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