|M5192||NSC59984||NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation.|
|M3159||Tenovin-3||Tenovin-3 increases p53 levels. Tenovin-3 increase K40 Ac-tubulin levels.|
|M2943||Pifithrin-μ||Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.|
|M2891||NSC 319726||NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells.|
|M2578||RITA||RITA (NSC 652287) is a MDM2 inhibitor and DNA damage agent for A498 (wild type) and TK-10 (mutation) cell lines with a GI50 of 17 nM and 32 nM, respectively.|
|M2570||Tenovin-6||Tenovin-6 is a small molecule activator of p53 transcriptional activity.|
|M2068||JNJ-26854165||JNJ-26854165 (Serdemetan) is a novel activator of p53 capable of inducing apoptosis in cancer cell lines.|
|M2036||Pifithrin-α||Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis.|
|M2027||Tenovin-1||Tenovin-1 is a small molecule activator of p53 transcriptional activity.|
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