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Abmole Inhibitor Catalog 2017

p53 Tumor protein p53


Cat.No.  Name Information
M10394 FL118 FL118 is an inhibitor of human survivin expression, activating tumor suppressor p53 as a novel MOA in p53 wild-type cancer cells.
M9623 APR-246 (Eprenetapopt) APR-246 (Eprenetapopt), also known as PRIMA-1MET, is a quinuclidinone derivative that targets the Wrap53 gene with potential antineoplastic activity.
M9302 CBL0137 CBL0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-κB with an EC50 of 0.47 µM.
M7994 PRIMA-1 PRIMA-1 is a selective re-activator of mutant p53 activity in tumor cells, and an inducer of apoptosis and inhibitor of growth of human tumors with mutant p53.
M7135 PhiKan 083 hydrochloride PhiKan 083 is a p53 stabilizing agent.
M6301 SAR405838 MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.
M5192 NSC59984 NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation.
M3159 Tenovin-3 Tenovin-3 increases p53 levels. Tenovin-3 increase K40 Ac-tubulin levels.
M2943 Pifithrin-μ Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.
M2891 NSC 319726 NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells.
M2598 Inauhzin Inauhzin is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress(IC50=3 uM, in A549 cell).
M2578 RITA RITA (NSC 652287) is a MDM2 inhibitor and DNA damage agent for A498 (wild type) and TK-10 (mutation) cell lines with a GI50 of 17 nM and 32 nM, respectively.
M2570 Tenovin-6 Tenovin-6 is a small molecule activator of p53 transcriptional activity.
M2068 JNJ-26854165 JNJ-26854165 (Serdemetan) is a novel activator of p53 capable of inducing apoptosis in cancer cell lines.
M2036 Pifithrin-α Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis.
M2027 Tenovin-1 Tenovin-1 is a small molecule activator of p53 transcriptional activity.

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