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p53 Tumor protein p53

Inhibitors

Cat.No.  Name Information
M2943 Pifithrin-μ Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.
M2036 Pifithrin-α Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis.
M20697 Triglycidyl Isocyanurate (Teroxirone) Triglycidyl Isocyanurate, also known as Teroxirone, is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl Isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. Triglycidyl Isocyanurate is also used in various polyester powder coatings in the metal finishing industry.
M13553 Milademetan tosylate hydrate Milademetan (DS-3032) tosylate hydrate is a specific and orally active MDM2 inhibitor for the research of acute myeloid leukemia (AML) or solid tumors.
M13552 CTX1 CTX1 is a p53 activator that overcomes HdmX-mediated p53 repression. CTX1 exhibits potent anti-cancer activity in a mouse acute myeloid leukemia (AML) model system.
M13551 COTI-2 COTI-2, an anti-cancer drug with low toxicity, is an orally available third generation activator of p53 mutant forms.
M13550 Amifostine thiol Amifostine thiol (WR-1065) is an active metabolite of the cytoprotector Amifostine . Amifostine thiol is a cytoprotective agent with radioprotective abilities. Amifostine thiol activates p53 through a JNK-dependent signaling pathway.
M11512 CBL0137 hydrochloride CBL0137 hydrochloride is an inhibitor of FACT, the histone molecule chaperone. FACT promotes the formation of chromatin transcription complexes. CBL0137 hydrochlorideye also activated p53 and inhibited NF-κB, with EC50 values of 0.37 and 0.47 μM, respectively.
M10394 FL118 FL118 is an inhibitor of human survivin expression, activating tumor suppressor p53 as a novel MOA in p53 wild-type cancer cells.
M9623 APR-246 (Eprenetapopt) APR-246 (Eprenetapopt) is the first small molecule to restore wild-type p53 function in TP53 mutant cells. Prima-1met also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of REDOX balance in cells.
M9302 CBL0137 CBL0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-κB with an EC50 of 0.47 µM.
M7994 PRIMA-1 PRIMA-1 is a selective re-activator of mutant p53 activity in tumor cells, and an inducer of apoptosis and inhibitor of growth of human tumors with mutant p53.
M7135 PhiKan 083 hydrochloride PhiKan 083 is a p53 stabilizing agent.
M6301 SAR405838 MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.
M5192 NSC59984 NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation.
M4558 Ziyuglycoside-I Ziyuglycoside I, isolated from S. officinalis root, has anti-wrinkle activity and increases type I collagen expression. Ziyuglycoside I can be used as an active ingredient in cosmetics. Ziyuglycoside I can induce p53-mediated cell cycle arrest and apoptosis, which can be used in the study of triple negative breast cancer.
M3159 Tenovin-3 Tenovin-3 increases p53 levels. Tenovin-3 increase K40 Ac-tubulin levels.
M2943 Pifithrin-μ Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.
M2598 Inauhzin Inauhzin is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress(IC50=3 uM, in A549 cell).
M2578 RITA RITA (NSC 652287) is a MDM2 inhibitor and DNA damage agent for A498 (wild type) and TK-10 (mutation) cell lines with a GI50 of 17 nM and 32 nM, respectively.
M2570 Tenovin-6 Tenovin-6 is a small molecule activator of p53 transcriptional activity.
M2068 JNJ-26854165 JNJ-26854165 (Serdemetan) is a novel activator of p53 capable of inducing apoptosis in cancer cell lines.



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