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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M9623 | APR-246 | APR-246, also known as PRIMA-1MET, is a quinuclidinone derivative that targets the Wrap53 gene with potential antineoplastic activity. |
| M9302 | CBL0137 | CBL0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-κB with an EC50 of 0.47 µM. |
| M7994 | PRIMA-1 | PRIMA-1 is a selective re-activator of mutant p53 activity in tumor cells, and an inducer of apoptosis and inhibitor of growth of human tumors with mutant p53. |
| M6301 | SAR405838 | MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1. |
| M5192 | NSC59984 | NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation. |
| M3159 | Tenovin-3 | Tenovin-3 increases p53 levels. Tenovin-3 increase K40 Ac-tubulin levels. |
| M2943 | Pifithrin-μ | Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy. |
| M2891 | NSC 319726 | NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells. |
| M2598 | Inauhzin | Inauhzin is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress(IC50=3 uM, in A549 cell). |
| M2578 | RITA | RITA (NSC 652287) is a MDM2 inhibitor and DNA damage agent for A498 (wild type) and TK-10 (mutation) cell lines with a GI50 of 17 nM and 32 nM, respectively. |
| M2570 | Tenovin-6 | Tenovin-6 is a small molecule activator of p53 transcriptional activity. |
| M2068 | JNJ-26854165 | JNJ-26854165 (Serdemetan) is a novel activator of p53 capable of inducing apoptosis in cancer cell lines. |
| M2036 | Pifithrin-α | Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis. |
| M2027 | Tenovin-1 | Tenovin-1 is a small molecule activator of p53 transcriptional activity. |
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