|M9623||APR-246||APR-246, also known as PRIMA-1MET, is a quinuclidinone derivative that targets the Wrap53 gene with potential antineoplastic activity.|
|M9302||CBL0137||CBL0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-κB with an EC50 of 0.47 µM.|
|M7994||PRIMA-1||PRIMA-1 is a selective re-activator of mutant p53 activity in tumor cells, and an inducer of apoptosis and inhibitor of growth of human tumors with mutant p53.|
|M6301||SAR405838||MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.|
|M5192||NSC59984||NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation.|
|M3159||Tenovin-3||Tenovin-3 increases p53 levels. Tenovin-3 increase K40 Ac-tubulin levels.|
|M2943||Pifithrin-μ||Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.|
|M2891||NSC 319726||NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells.|
|M2598||Inauhzin||Inauhzin is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress(IC50=3 uM, in A549 cell).|
|M2578||RITA||RITA (NSC 652287) is a MDM2 inhibitor and DNA damage agent for A498 (wild type) and TK-10 (mutation) cell lines with a GI50 of 17 nM and 32 nM, respectively.|
|M2570||Tenovin-6||Tenovin-6 is a small molecule activator of p53 transcriptional activity.|
|M2068||JNJ-26854165||JNJ-26854165 (Serdemetan) is a novel activator of p53 capable of inducing apoptosis in cancer cell lines.|
|M2036||Pifithrin-α||Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis.|
|M2027||Tenovin-1||Tenovin-1 is a small molecule activator of p53 transcriptional activity.|
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