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ELX-02 disulfate

Cat. No. M21478
ELX-02 disulfate Structure
Synonym:

NB-124 disulfate

Size Price Availability Quantity
1mg USD 550  USD550 In stock
5mg USD 980  USD980 In stock
10mg USD 1500  USD1500 In stock
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Quality Control & Documentation
Biological Activity

ELX-02 disulfate (NB-124 disulfate) is a first-in-class synthetic eukaryotic ribosomal specific glycoside (ERSG) that can be used to study genetic diseases caused by nonsense mutations.

Chemical Information
Molecular Weight 580.6
Formula C19H40N4O14S
CAS Number 2244622-33-9
Solubility (25°C) Water ≥ 60 mg/mL
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] E de Poel, et al. J Cyst Fibros. Functional Restoration of CFTR Nonsense Mutations in Intestinal Organoids

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