Synonym: NSC 303580, PFTμ
Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO 20 mg/mL|
|Source||APMIS.m (2017). Figure 7. Pifithrin-μ (Abmole Bioscience Inc. Houston, TX, USA)|
|Cell Lines||HeLa cells|
|Results||Particularly, pifithrin-μ and WZ4003 dramatically decreased 10-G-induced activation of the p53 and p-AMPK protein, respectively.|
J Agric Food Chem. 2017 Mar 15;65(10):2089-2099.
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