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Spermine

Cat. No. M9387
Spermine Structure
Synonym:

Neuridine

Size Price Availability Quantity
100mg USD 40 In stock
500mg USD 80 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%, for cell culture
  • COA
  • MSDS
Biological Activity

Spermine is a biogenic polyamine formed from spermidine and occurs in almost all tissues. It is essential for both neoplastic and normal tissue growth and is involved in the modulation of calcium-dependent immune processes. Spermine inhibits NOS1 (nNOS). Spermine binds to and activates NMDA and has been shown to potentiate NMDA-induced currents in a concentration-dependent manner. Spermine is a GluR inhibitor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 202.34
Formula C10H26N4
CAS Number 71-44-3
Purity >98%, for cell culture
Solubility Water ≥ 50 mg/mL
Storage 2-8°C, dry, protect from light, sealed
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Spermine, Neuridine supplier, inhibitors

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